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Prenatal and postnatal exposure to NO2 and child attentional function at 4-5 years of age

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dc.contributor.author Sentís, Alexis
dc.contributor.author Sunyer Deu, Jordi
dc.contributor.author Dalmau Bueno, Albert
dc.contributor.author Andiarena, Ainara
dc.contributor.author Ballester Díez, Ferran
dc.contributor.author Cirach, Marta
dc.contributor.author Estarlich, Marisa
dc.contributor.author Fernández-Somoano, Ana
dc.contributor.author Ibarluzea, Jesús
dc.contributor.author Íñiguez, Carmen
dc.contributor.author Lertxundi, Aitana
dc.contributor.author Tardón, Adonina
dc.contributor.author Nieuwenhuijsen, Mark J.
dc.contributor.author Vrijheid, Martine
dc.contributor.author Guxens Junyent, Mònica
dc.date.accessioned 2018-06-15T07:47:08Z
dc.date.issued 2017
dc.identifier.citation Sentís A, Sunyer J, Dalmau-Bueno A, Andiarena A, Ballester F, Cirach M et al. Prenatal and postnatal exposure to NO2 and child attentional function at 4-5years of age. Environ Int. 2017 Sep;106:170-7. DOI: 10.1016/j.envint.2017.05.021
dc.identifier.issn 0160-4120
dc.identifier.uri http://hdl.handle.net/10230/34907
dc.description.abstract BACKGROUND: Prenatal and postnatal exposure to air pollution has been linked to cognitive impairment in children, but very few studies have assessed its association with attentional function. OBJECTIVES: To evaluate the association between prenatal and postnatal exposure to nitrogen dioxide (NO2) and attentional function in children at 4-5years of age. METHODS: We used data from four regions of the Spanish INMA-Environment and Childhood-Project, a population-based birth cohort. Using land-use regression models (LUR), we estimated prenatal and postnatal NO2 levels in all of these regions at the participants' residential addresses. We assessed attentional function using the Kiddie-Conners Continuous Performance Test (K-CPT). We combined the region-specific adjusted effect estimates using random-effects meta-analysis. RESULTS: We included 1298 children with complete data. Prenatal exposure to NO2 was associated with an impaired standard error of the hit reaction time (HRT(SE)) (increase of 1.12ms [95% CI; 0.22 a 2.02] per 10μg/m3 increase in prenatal NO2) and increased omission errors (6% [95% CI; 1.01 to 1.11] per 10μg/m3 increase in prenatal NO2). Postnatal exposure to NO2 resulted in a similar but borderline significant increase of omission errors (5% [95% CI; =0.99 to 1.11] per 10μg/m3 increase in postnatal NO2). These associations did not vary markedly between regions, and were mainly observed in girls. Commission errors and lower detectability were associated with prenatal and postnatal exposure to NO2 only in some regions. CONCLUSIONS: This study indicates that higher exposure to ambient NO2, mainly during pregnancy and to a lesser extent postnatally, is associated with impaired attentional function in children at 4-5years of age.
dc.description.sponsorship This study was funded by grants from the Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041 and PI031615; PI041931; PI041112; PI041436; PI041509; PI042018; PI051079; PI051052; PI060867; PI061213; PI070314; CP1100178; PI081151 incl. FEDER funds; PS0900090 incl. FEDER funds; PI0902311 incl. FEDER funds; PI0902647 incl. FEDER funds; PI1102591 incl. FEDER funds; PI1102038 incl. FEDER funds; PI131944 incl. FEDER funds; PI132032 incl. FEDER funds; PI1302429 incl. FEDER funds; PI1302187 incl. FEDER funds; PI140891 incl. FEDER funds; PI141687 incl. FEDER funds and MS13/00054), Generalitat de Catalunya-CIRIT 1999SGR 00241, Fundació La marató de TV3 (090430), Department of Health of the Basque Government (2005111093, 2009111069 and 2013111089), the Provincial Government of Gipuzkoa (DFG06/002 and DFG08/001), Convenios anuales con los ayuntamientos de la zona del estudio (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain), from UE (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1), from the European Research Council under the ERC Grant Agreement number ERC-AdG 2010 GA#268479 – the BREATHE project, from the Conselleria de Sanitat of Generalitat Valenciana (AP212/11, 002/008, 012/009, 013/2009, 014/009, 015/008, 016/009, 021/007, 021/008, 023/008 and 024/007) and from Obra Social Cajastur/Fundación Liberbank and Universidad de Oviedo. ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Environment International. 2017 Sep;106:170-7
dc.rights © Elsevier http://dx.doi.org/10.1016/j.envint.2017.05.021
dc.subject.other Aire -- Contaminació
dc.subject.other Diòxids de nitrogen
dc.subject.other Embaràs
dc.subject.other Trastorn per dèficit d'atenció amb hiperactivitat
dc.title Prenatal and postnatal exposure to NO2 and child attentional function at 4-5 years of age
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.envint.2017.05.021
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/282957
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/268479
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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