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Extinction and reinstatement of an operant responding maintained by food in different models of obesity

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dc.contributor.author Burokas, Aurelijus, 1982-
dc.contributor.author Martín García, Elena, 1975-
dc.contributor.author Espinosa-Carrasco, José
dc.contributor.author Erb, Ionas
dc.contributor.author McDonald, Jerome
dc.contributor.author Notredame, Cedric
dc.contributor.author Dierssen, Mara
dc.contributor.author Maldonado, Rafael, 1961-
dc.date.accessioned 2018-06-12T09:30:38Z
dc.date.issued 2018
dc.identifier.citation Burokas A, Martín-García E, Espinosa-Carrasco J, Erb I, McDonald J, Notredame C et al. Extinction and reinstatement of an operant responding maintained by food in different models of obesity. Addict Biol. 2018 Mar;23(2):544-55. DOI: 10.1111/adb.12597
dc.identifier.issn 1355-6215
dc.identifier.uri http://hdl.handle.net/10230/34877
dc.description.abstract A major problem in treating obesity is the high rate of relapse to abnormal food-taking habits after maintaining an energy balanced diet. Alterations of eating behavior such as compulsive-like behavior and lack of self-control over food intake play a critical role in relapse. In this study, we used an operant paradigm of food-seeking behavior on two different diet-induced obesity models, a free-choice chocolate-mixture diet and a high-fat diet with face validity for a rapid development of obesity or for unhealthy food regularly consumed in our societies. A reduced operant performance and motivation for the hedonic value of palatable chocolate pellets was revealed in both obesity mouse models. However, only mice exposed to high-fat diet showed an increased compulsive-like behavior in the absence of the reinforcer further characterized by impaired operant learning, enhanced impulsivity and intensified inflexibility. We used principal component analysis to globally identify the specific behaviors responsible for the differences among diet groups. Learning impairment and inflexible behaviors contributed to a first principal component, explaining the largest proportion of the variance in the high-fat diet mice phenotype. Reinforcement, impulsion and compulsion were the main contributors to the second principal component explaining the differences in the chocolate-mixture mice behavioral phenotype. These behaviors were not exclusive of chocolate group because some high-fat individuals showed similar values on this component. These data indicate that extended access to hypercaloric diets differentially modifies operant behavior learning, behavioral flexibility, impulsive-like and compulsive-like behavior, and these effects were dependent on the exposure to each specific diet.
dc.description.sponsorship This work was supported by the DG Research of the European Commission FP7 (#HEALTH-F2 2013-602891 and PHECOMP #LHSM-CT-2007-037669), the Spanish ‘RETICS-Instituto de Salud Carlos III’ (#RD16/0017/0020), the Spanish ‘Ministerio de Economia y Competitividad’ (#SAF-2014-59648P), the ‘Plan nacional sobre drogas’ (#PNSD-2013-5068), the Catalan Government ‘AGAUR-Generalitat de Catalunya’ (#2014-SGR-1547) and the Catalan foundation ‘La Marató de TV3’ (#2016/20-30). The laboratory of M.D. is supported by DIUE de la Generalitat de Catalunya (Grups consolidats SGR 2014/1125). This work was supported by Fondation Jérôme Lejeune (Paris, France), MINECO (SAF2013-49129-C2-1-R), CDTI (‘Smartfoods’) and EU (Era Net Neuron PCIN-2013-060). The CRG is a Center of Excellence Severo Ochoa SEV-2012-0208. The CIBER of Rare Diseases is an initiative of the ISCIII. The laboratory of C.N. acknowledges the funding from the Spanish Ministry of Economy and Finance (MINECO), grant number BFU2011-28575. J.E. receivedthe FI grant from Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR) de la Generalitat de Catalunya
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Addiction Biology. 2018 Mar;23(2):544-55
dc.rights This is the pre-peer reviewed version of the following article: Burokas A, Martín-García E, Espinosa-Carrasco J, Erb I, McDonald J, Notredame C et al. Extinction and reinstatement of an operant responding maintained by food in different models of obesity. Addict Biol. 2018 Mar;23(2):544-555, which has been published in final form at http://dx.doi.org/10.1111/adb.12597. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
dc.subject.other Obesitat
dc.subject.other Conducta compulsiva
dc.subject.other Trastorns de la conducta alimentària
dc.subject.other Malalties -- Recaiguda
dc.title Extinction and reinstatement of an operant responding maintained by food in different models of obesity
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1111/adb.12597
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/602891
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF-2014-59648P
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2013-49129-C2-1-R
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2011-28575
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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