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Phylogenetic analyses uncover a novel clade of transferrin in nonmammalian vertebrates

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dc.contributor.author Mohd-Padil, Hirzahida
dc.contributor.author Mohd-Adnan, Adura
dc.contributor.author Gabaldón Estevan, Juan Antonio, 1973-
dc.date.accessioned 2018-06-07T07:51:57Z
dc.date.available 2018-06-07T07:51:57Z
dc.date.issued 2013
dc.identifier.citation Mohd-Padil H, Mohd-Adnan A, Gabaldón T. Phylogenetic analyses uncover a novel clade of transferrin in nonmammalian vertebrates. Mol Biol Evol. 2013; 30(4): 894-905. DOI: 10.1093/molbev/mss325
dc.identifier.issn 0737-4038
dc.identifier.uri http://hdl.handle.net/10230/34844
dc.description.abstract Transferrin is a protein super-family involved in iron transport, a central process in cellular homeostasis. Throughout the evolution of vertebrates, transferrin members have diversified into distinct subfamilies including serotransferrin, ovotransferrin, lactoferrin, melanotransferrin, the inhibitor of carbonic anhydrase, pacifastin, and the major yolk protein in sea urchin. Previous phylogenetic analyses have established the branching order of the diverse transferrin subfamilies but were mostly focused on the transferrin repertoire present in mammals. Here, we conduct a comprehensive phylogenetic analysis of transferrin protein sequences in sequenced vertebrates, placing a special focus on the less-studied nonmammalian vertebrates. Our analyses uncover a novel transferrin clade present across fish, sauropsid, and amphibian genomes but strikingly absent from mammals. Our reconstructed scenario implies that this novel class emerged through a duplication event at the vertebrate ancestor, and that it was subsequently lost in the lineage leading to mammals. We detect footprints of accelerated evolution following the duplication event, which suggest positive selection and early functional divergence of this novel clade. Interestingly, the loss of this novel class of transferrin in mammals coincided with the divergence by duplication of lactoferrin and serotransferrin in this lineage. Altogether, our results provide novel insights on the evolution of iron-binding proteins in the various vertebrate groups.
dc.description.sponsorship This work was supported by grants from the Malaysian Ministry of Science, Technology and Innovation (07-05-MGI-GMB009), the Spanish Ministry of Science and Innovation (BFU2009-09168), and Universiti Kebangsaan Malaysia (UKM-DLP-2011-027)
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Oxford University Press
dc.rights © 2013 Hirzahida Mohd-Padil, Adura Mohd-Adnan, Toni Gabaldón. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited
dc.rights.uri http://creativecommons.org/licenses/by-nc/3.0/
dc.subject.other Filogènia
dc.subject.other Transferrina
dc.subject.other Vertebrats
dc.title Phylogenetic analyses uncover a novel clade of transferrin in nonmammalian vertebrates
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1093/molbev/mss325
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2009-09168
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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