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Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney

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dc.contributor.author Wain, Louise V.
dc.contributor.author Marrugat de la Iglesia, Jaume
dc.contributor.author Elosua Llanos, Roberto
dc.contributor.author Ehret, Georg B.
dc.date.accessioned 2018-06-05T07:18:38Z
dc.date.issued 2017
dc.identifier.citation Wain LV, Vaez A, Jansen R, Joehanes R, van der Most PJ, Erzurumluoglu AM. et al. Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney. Hypertension. 2017;70(3):e4-19. DOI: 10.1161/HYPERTENSIONAHA.117.09438
dc.identifier.issn 0194-911X
dc.identifier.uri http://hdl.handle.net/10230/34820
dc.description.abstract Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA Combining large whole-blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher American Hearth Association
dc.relation.ispartof Hypertension. 2017;70(3):e4-19
dc.rights © American Hearth Association http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09438
dc.subject.other Hipertensió
dc.subject.other Sistema cardiovascular -- Malalties
dc.title Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09438
dc.subject.keyword GWAS
dc.subject.keyword Blood pressure
dc.subject.keyword Cardiovascular risk
dc.subject.keyword Complex traits
dc.subject.keyword eSNP
dc.subject.keyword Hypertension
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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