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A study on the bioequivalence of lithium and valproate salivary and blood levels in the treatment of bipolar disorder

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dc.contributor.author Murru, Andrea
dc.contributor.author Torra, Mercè
dc.contributor.author Callari, Antonio
dc.contributor.author Pacchiarotti, Isabella
dc.contributor.author Romero, Sergio
dc.contributor.author Gonzalez de la Presa, Bernardino
dc.contributor.author Varo, Cristina
dc.contributor.author Goikolea, Jose M.
dc.contributor.author Pérez Solá, Victor
dc.contributor.author Vieta, Eduard
dc.contributor.author Colom, Francesc
dc.date.accessioned 2018-05-23T07:28:29Z
dc.date.issued 2017
dc.identifier.citation Murru A, Torra M, Callari A, Pacchiarotti I, Romero S, Gonzalez de la Presa B. et al. A study on the bioequivalence of lithium and valproate salivary and blood levels in the treatment of bipolar disorder. Eur Neuropsychopharmacol. 2017 Aug;27(8):744-750. DOI: 10.1016/j.euroneuro.2017.06.003
dc.identifier.issn 0924-977X
dc.identifier.uri http://hdl.handle.net/10230/34705
dc.description.abstract Lithium (Li) and valproate (VPA) are used in the treatment of bipolar disorder (BD), with narrow therapeutic window requiring periodic control of serum levels. This prevents intoxication, lack of efficacy due to low serum concentrations, and allows monitoring adherence. We aimed at evaluating the bioequivalence of salivary and blood levels of LI or VPA in a sample of adult BD patients. Secondarily, lithium bioequivalence was evaluated across different patients' lifespans. BD patients treated with either Li or VPA underwent contemporary standard serum and salivary measurements. Blood levels of both drugs were taken according to standard procedures. Li salivary levels were performed by an adapted potentiometric method on the AVL9180 electrolyte analyzer. VPA salivary levels were taken with an immune-assay method with turbidimetric inhibition. A total of 50 patients (38 on Li, 12 on VPA) were enrolled. Blood-saliva bioequivalence for VPA was not found due to a high variability in salivary measures. Li measures resulted in a high correlation (r=0.767, p<0.001), showing no partial correlation with age (r=0.147, p=0.380). Li salivary test is a reliable method of measuring Li availability and is equivalent to serum levels. Potential advantages of Li salivary testing are its non-invasive nature and the possibility of doing the test during the usual appointment with the psychiatrist.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof European Neuropsychopharmacology. 2017 Aug;27(8):744-50
dc.rights © Elsevier http://dx.doi.org/10.1016/j.euroneuro.2017.06.003
dc.subject.other Trastorn bipolar -- Tractament
dc.title A study on the bioequivalence of lithium and valproate salivary and blood levels in the treatment of bipolar disorder
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.euroneuro.2017.06.003
dc.subject.keyword Bioequivalence
dc.subject.keyword Bipolar disorders
dc.subject.keyword Lithium
dc.subject.keyword Salivary
dc.subject.keyword Serum levels
dc.subject.keyword Valproate
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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