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Acid-base safety during the course of a very low-calorie-ketogenic diet

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dc.contributor.author Gomez-Arbelaez, Diego
dc.contributor.author Crujeiras, Ana B.
dc.contributor.author Castro, Ana I.
dc.contributor.author Goday Arno, Alberto
dc.contributor.author Mas-Lorenzo, Antonio
dc.contributor.author Bellon, Ana
dc.contributor.author Tejera, Cristina
dc.contributor.author Bellido, Diego
dc.contributor.author Galban, Cristobal
dc.contributor.author Sajoux, Ignacio
dc.contributor.author Lopez-Jaramillo, Patricio
dc.contributor.author Casanueva, Felipe F.
dc.date.accessioned 2018-05-15T07:11:06Z
dc.date.available 2018-05-15T07:11:06Z
dc.date.issued 2017
dc.identifier.citation Gomez-Arbelaez D, Crujeiras AB, Castro AI, Goday A, Mas-Lorenzo A, Bellon A.et al. Acid-base safety during the course of a very low-calorie-ketogenic diet. Endocrine. 2017 Oct;58(1):81-90. DOI: 10.1007/s12020-017-1405-3
dc.identifier.issn 1355-008X
dc.identifier.uri http://hdl.handle.net/10230/34629
dc.description.abstract BACKGROUND AND AIMS: Very low-calorie ketogenic (VLCK) diets have been consistently shown to be an effective obesity treatment, but the current evidence for its acid-base safety is limited. The aim of the current work was to evaluate the acid-base status of obese patients during the course of a VLCK diet. METHOD: Twenty obese participants undertook a VLCK diet for 4 months. Anthropometric and biochemical parameters, and venous blood gases were obtained on four subsequent visits: visit C-1 (baseline); visit C-2, (1-2 months); maximum ketosis; visit C-3 (2-3 months), ketosis declining; and visit C-4 at 4 months, no ketosis. Results were compared with 51 patients that had an episode of diabetic ketoacidosis as well as with a group that underwent a similar VLCK diet in real life conditions of treatment. RESULTS: Visit C1 blood pH (7.37 ± 0.03); plasma bicarbonate (24.7 ± 2.5 mmol/l); plasma glucose (96.0 ± 11.7 mg/l) as well as anion gap or osmolarity were not statistically modified at four months after a total weight reduction of 20.7 kg in average and were within the normal range throughout the study. Even at the point of maximum ketosis all variables measured were always far from the cut-off points established to diabetic ketoacidosis. CONCLUSION: During the course of a VLCK diet there were no clinically or statistically significant changes in glucose, blood pH, anion gap and plasma bicarbonate. Hence the VLCK diet can be considered as a safe nutritional intervention for the treatment of obesity in terms of acid-base equilibrium.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Endocrine. 2017 Oct;58(1):81-90
dc.rights Copyright © The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.other Dieta hipocalòrica
dc.subject.other Acidosi
dc.title Acid-base safety during the course of a very low-calorie-ketogenic diet
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1007/s12020-017-1405-3
dc.subject.keyword Acidosis
dc.subject.keyword Acid–base safety
dc.subject.keyword Ketogenic diet
dc.subject.keyword Ketosis
dc.subject.keyword Obesity
dc.subject.keyword Very low-energy diet
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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