Welcome to the UPF Digital Repository

Prenatal exposure to perfluoroalkyl substances and cardiometabolic risk in children from the spanish INMA birth cohort study

Show simple item record

dc.contributor.author Manzano Salgado, Cyntia Beatriz, 1987-
dc.contributor.author Casas Sanahuja, Maribel
dc.contributor.author Lopez-Espinosa, Maria-José
dc.contributor.author Ballester Díez, Ferran
dc.contributor.author Iñiguez, Carmen
dc.contributor.author Martínez Muriano, David
dc.contributor.author Romaguera Bosch, Dora
dc.contributor.author Fernández-Barrés, Sílvia
dc.contributor.author Santa Marina, Loreto
dc.contributor.author Basterrechea, Mikel
dc.contributor.author Schettgen, Thomas
dc.contributor.author Valvi, Damaskini, 1983-
dc.contributor.author Vioque, Jesus
dc.contributor.author Sunyer Deu, Jordi
dc.contributor.author Vrijheid, Martine
dc.date.accessioned 2018-03-01T14:49:25Z
dc.date.available 2018-03-01T14:49:25Z
dc.date.issued 2017
dc.identifier.citation Manzano-Salgado CB, Casas M, Lopez-Espinosa MJ, Ballester F, Iñiguez C, Martinez D et al. Prenatal exposure to perfluoroalkyl substances and cardiometabolic risk in children from the spanish INMA birth cohort study. Environ Health Perspect. 2017 Sep 20;125(9):097018. DOI: 10.1289/EHP1330
dc.identifier.issn 0091-6765
dc.identifier.uri http://hdl.handle.net/10230/34028
dc.description.abstract BACKGROUND: Perfluoroalkyl substances (PFAS) may affect body mass index (BMI) and other components of cardiometabolic (CM) risk during childhood, but evidence is scarce and inconsistent. OBJECTIVES: We estimated associations between prenatal PFAS exposures and outcomes relevant to cardiometabolic risk, including a composite CM-risk score. METHODS: We measured perfluorohexanesulfonic acid (PFHxS), perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) in maternal plasma (first trimester). We assessed weight gain from birth until 6 mo. At 4 and 7 y, we calculated the age- and sex-specific z-scores for BMI, waist circumference (WC), and blood pressure (BP) (n≈1,000). At age 4, we calculated the age-, sex-, and region-specific z-scores for cholesterol, triglycerides (TGs), high-density (HDL-C), and low-density lipoprotein cholesterol (LDL-C) (n=627). At age 4, we calculated a CM-risk score (n=386) as the sum of the individual age-, sex-, and region-specific z-scores for WC, BP, HDL-C, and TGs. We used the average between the negative of HDL-C z-score and TGs z-score to give similar weight to lipids and the other components in the score. A higher score indicates a higher cardiometabolic risk at age 4. RESULTS: PFOS and PFOA were the most abundant PFAS (geometric mean: 5.80 and 2.32 ng/mL, respectively). In general, prenatal PFAS concentrations were not associated with individual outcomes or the combined CM-risk score. Exceptions were positive associations between prenatal PFHxS and TGs z-score [for a doubling of exposure, β=0.11; 95% confidence interval (CI): 0.01, 0.21], and between PFNA and the CM-risk score (β=0.60; 95% CI: 0.04, 1.16). There was not clear or consistent evidence of modification by sex. CONCLUSIONS: We observed little or no evidence of associations between low prenatal PFAS exposures and outcomes related to cardiometabolic risk in a cohort of Spanish children followed from birth until 7 y. https://doi.org/10.1289/EHP1330
dc.description.sponsorship This study was funded by grants from the European Union (FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5-1), and from Spain: Instituto de Salud Carlos III and Ministry of Health (Red INMA G03/176; CB06/02/0041; PI041436, PI081151, PI06/0867, PS09/00090, PI13/02187; FIS-FEDER: PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/1213, PI07/0314, PI09/02647, PI11/01007, PI11/02591, PI11/02038, PI12/01890, PI13/1944, PI13/2032, PI14/00891, and PI14/1687; predoctoral grant PFIS - FI14/00099; and Miguel Servet-FEDER: CP11/0178 and CPII16/00051), CIBERESP; the Conselleria de Sanitat, Generalitat Valenciana; Department of Health of the Basque Government (2005111093 and 2009111069); the Provincial Government of Gipuzkoa (DFG06/004 and DFG08/001); and the Generalitat de Catalunya-CIRIT (1999SGR 00241); and from the United Stated of America: National Institute of Environmental Health Sciences of the National Institutes of Health (NIH) (grant number ES021477). ISGlobal is a member of the Centres de Recerca de Catalunya (CERCA) Programme, Generalitat de Catalunya. This study has been reviewed and approved by the accredited committees of the following institutions: the Municipal Institute of Sanitary Assistance of Barcelona, La Fe University Hospital of Valencia, and Donostia Hospital de Zumarraga.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher National Institute of Environmental Health Sciences
dc.relation.ispartof Environmental Health Perspectives. 2017 Sep 20;125(9):097018
dc.rights Reproduced from Environmental Health Perspectives http://dx.doi.org/10.1289/EHP1330
dc.title Prenatal exposure to perfluoroalkyl substances and cardiometabolic risk in children from the spanish INMA birth cohort study
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1289/EHP1330
dc.subject.keyword Alkanesulfonic acids/blood
dc.subject.keyword Caprylates/blood
dc.subject.keyword Environmental pollutants/blood
dc.subject.keyword Prenatal exposure
dc.subject.keyword Maternal exposure
dc.subject.keyword Environmental exposure
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/282957
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search


My Account


In collaboration with Compliant to Partaking