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Detection of IgE reactivity to a handful of allergen molecules in early childhood predicts respiratory allergy in adolescence

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dc.contributor.author Wickman, Magnus
dc.contributor.author Lupinek, Christian
dc.contributor.author Andersson, Niklas
dc.contributor.author Belgrave, Danielle
dc.contributor.author Asarnoj, Anna
dc.contributor.author Benet, Marta
dc.contributor.author Pinart, Mariona
dc.contributor.author Wieser, Sandra
dc.contributor.author García Aymerich, Judith
dc.contributor.author Baar, Alexandra
dc.contributor.author Pershagen, Göran
dc.contributor.author Simpson, Angela
dc.contributor.author Kull, Inger
dc.contributor.author Bergström, Anna
dc.contributor.author Melén, Erik
dc.contributor.author Hamsten, Carl
dc.contributor.author Antó i Boqué, Josep Maria
dc.contributor.author Bousquet, Jean
dc.contributor.author Custovic, Adnan
dc.contributor.author Valenta, Rudolf
dc.contributor.author van Hage, Marianne
dc.date.accessioned 2018-03-01T14:49:15Z
dc.date.available 2018-03-01T14:49:15Z
dc.date.issued 2017
dc.identifier.citation Wickman M, Lupinek C, Andersson N, Belgrave D, Asarnoj A, Benet M et al. Detection of IgE reactivity to a handful of allergen molecules in early childhood predicts respiratory allergy in adolescence. EBioMedicine. 2017 Dec;26:91-99. DOI: 10.1016/j.ebiom.2017.11.009
dc.identifier.issn 2352-3964
dc.identifier.uri http://hdl.handle.net/10230/34026
dc.description.abstract BACKGROUND: Sensitization in early childhood may precede respiratory allergy in adolescence. METHODS: IgE reactivity against 132 allergen molecules was evaluated using the MeDALL microarray in sera obtained from a random sample of 786 children at the age of 4, 8 and 16years in a population based birth cohort (BAMSE). Symptoms were analyzed by questionnaire at ages 4, 8 and 16years. Clinically and independent relevant allergen molecules accounting for ≥90% of IgE reactivities in sensitized individuals and at all time-points were identified as risk molecules and used to predict respiratory allergy. The data was replicated in the Manchester Asthma and Allergy Study (MAAS) birth cohort by studying IgE reactivity with the use of a commercial IgE microarray. Sera were obtained from children at the ages of 3, 5, 8 and 11years (N=248) and the outcome was studied at 11years. FINDINGS: In the BAMSE cohort 4 risk molecules could be identified, i.e.: Ara h 1 (peanut), Bet v 1 (birch), Fel d 1 (cat), Phl p 1 (grass). For MAAS the corresponding number of molecules was 5: Der p 1 (dust mite), Der f 2 (dust mite), Phl p 1 (grass), Phl p 5 (grass), Fel d 1 (cat). In BAMSE, early IgE reactivity to ≥3 of 4 allergen molecules at four years predicted incident and persistent asthma and/or rhinitis at 16years (87% and 95%, respectively). The corresponding proportions in the MAAS cohort at 16years were 100% and 100%, respectively, for IgE reactivity to ≥3 of 5 risk molecules. INTERPRETATIONS: IgE reactivity to a few allergen molecules early in life identifies children with a high risk of asthma and/or rhinitis at 16years. These findings will be of importance for developing preventive strategies for asthma and rhinitis in children.
dc.description.sponsorship This study was supported by research grants from the Swedish Asthma and Allergy Foundation, Stockholm County Council (ALF Medicin), Swedish Research Council, the Swedish Heart-Lung Foundation, the Swedish Cancer and Allergy Foundation, the King Gustaf V 80th Birthday Foundation, the Hesselman Foundation, The Konsul Th C Bergh Foundation, the Magnus Bergvall Foundation, Working Life and Welfare, grant F4605 of the Austrian Science Fund (FWF) and by the European Commission's Seventh Framework 29 Program MeDALL under grant agreement No. 261357. Danielle Belgrave is supported through the Medical Research Council Grant MR/M015181/1
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof EBioMedicine. 2017 Dec;26:91-99
dc.rights Copyright © 2017 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title Detection of IgE reactivity to a handful of allergen molecules in early childhood predicts respiratory allergy in adolescence
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.ebiom.2017.11.009
dc.subject.keyword Asthma
dc.subject.keyword IgE
dc.subject.keyword Rhinitis
dc.subject.keyword Sensitisation
dc.subject.keyword Prediction
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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