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The combination of MDPV and ethanol results in decreased cathinone and increased alcohol levels. Study of such pharmacological interaction

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dc.contributor.author López-Arnau, R.
dc.contributor.author Buenrostro-Jáuregui, M.
dc.contributor.author Muñoz-Villegas, P.
dc.contributor.author Rodríguez-Morató, Jose, 1987-
dc.contributor.author Ciudad-Roberts, A.
dc.contributor.author Duart, L.
dc.contributor.author Camarasa, J.
dc.contributor.author Torre Fornell, Rafael de la
dc.contributor.author Pubill, D.
dc.contributor.author Escubedo, Elena
dc.date.accessioned 2018-03-01T09:01:00Z
dc.date.issued 2017
dc.identifier.citation López-Arnau R, Buenrostro-Jáuregui M, Muñoz-Villegas P, Rodríguez-Morató J, Ciudad-Roberts A, Duart L. et al. The combination of MDPV and ethanol results in decreased cathinone and increased alcohol levels. Study of such pharmacological interaction. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jun 2;76:19-28. DOI: 10.1016/j.pnpbp.2017.02.011
dc.identifier.issn 0278-5846
dc.identifier.uri http://hdl.handle.net/10230/34022
dc.description.abstract Methylenedioxypyrovalerone (MDPV) is a new psychostimulant cathinone acting as a selective dopamine transporter blocker. Due to the concomitant consumption of ethanol (EtOH) and new psychoactive substances, it is of interest to explore a possible pharmacological interaction between MDPV and EtOH. In locomotor activity assays, EtOH (1g/kg i.p.) elicited a reduction in the stimulant effect induced by low doses of MDPV (0.1-0.3mg/kg, s.c.) in rats, jointly with a decrease in blood and brain MDPV concentrations. Experiments in rat liver microsomes showed different effects depending on the [MDPV]/[EtOH] relationship, evidencing, at certain concentrations, the enhancing effect of EtOH on MDPV metabolism. These suggest that EtOH interacts with MDPV at microsomal level, increasing its metabolic rate. The interaction between both substances was also supported by results in plasma EtOH concentration, which were significantly increased by MDPV, in such a manner that EtOH elimination rate was significantly reduced. The possible toxicological impact of this phenomenon deserves further investigation. In contrast, the rewarding properties of MDPV were unaltered by EtOH. Microdialysis experiments verified that, in the NAcc, both substances could also act synergistically, in such a manner that extracellular dopamine concentrations are maintained. Finally, if the psychostimulant effect induced by MDPV decreased with EtOH, it could favor the boosting and re-dosing in search of the desired effects. However, as the rewarding effect of each dose of the substance would not decrease, the addictive liability could increase considerably. Moreover, we must warn about the increase in EtOH concentrations when consumed concomitantly with MDPV.
dc.description.sponsorship Funding for this study was provided by Ministerio de Economia y Competitividad (grants number SAF2013-46135-P and SAF2016-75347-R) and CIBER de Fisiopatología de la Obesidad y Nutrición (CB06/03/0028) (CIBEROBN, Instituto de Salud Carlos III, Madrid, Spain). MB-J and PM-V are post-doctoral fellows (CONACyT post-doctoral grants 263473 and 265633).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.rights © Elsevier http://dx.doi.org/10.1016/j.pnpbp.2017.02.011
dc.subject.other Alcohol -- Efectes fisiològics
dc.subject.other Antidepressius
dc.title The combination of MDPV and ethanol results in decreased cathinone and increased alcohol levels. Study of such pharmacological interaction
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.pnpbp.2017.02.011
dc.subject.keyword 3,4-Methylenedioxypyrovalerone
dc.subject.keyword Conditioning
dc.subject.keyword Ethanol
dc.subject.keyword Interaction
dc.subject.keyword Psychostimulant
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2013-46135-P
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2016-75347-R
dc.rights.accessRights info:eu-repo/semantics/embargoedAccess
dc.type.version info:eu-repo/semantics/acceptedVersion
dc.embargo.liftdate 2018-06-30
dc.date.embargoEnd info:eu-repo/date/embargoEnd/2018-06-30

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