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MDMA-induced indifference to negative sounds is mediated by the 5-HT2A receptor

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dc.contributor.author Kuypers, Kim PC
dc.contributor.author Torre Fornell, Rafael de la
dc.contributor.author Farré Albaladejo, Magí
dc.contributor.author Pizarro Lozano, Mª Nieves
dc.contributor.author Xicota Vila, Laura, 1987-
dc.contributor.author Ramaekers, Johannes G.
dc.date.accessioned 2018-01-22T11:36:55Z
dc.date.available 2018-01-22T11:36:55Z
dc.date.issued 2018
dc.identifier.citation Kuypers KPC, de la Torre R, Farre M, Pizarro N, Xicota L, Ramaekers JG. MDMA-induced indifference to negative sounds is mediated by the 5-HT2A receptor. Psychopharmacology (Berl). 2018 Feb; 235(2): 481-490. DOI: 10.1007/s00213-017-4699-1
dc.identifier.issn 0033-3158
dc.identifier.uri http://hdl.handle.net/10230/33717
dc.description.abstract BACKGROUND: MDMA has been shown to induce feelings of sociability, a positive emotional bias and enhanced empathy. While previous research has used only visual emotional stimuli, communication entails more than that single dimension and it is known that auditory information is also crucial in this process. In addition, it is, however, unclear what the neurobiological mechanism underlying these MDMA effects on social behaviour is. Previously, studies have shown that MDMA-induced emotional excitability and positive mood are linked to the action on the serotonin (5-HT) 2A receptor. AIM: The present study aimed at investigating the effect of MDMA on processing of sounds (Processing of Affective Sounds Task (PAST)) and cognitive biases (Approach-Avoidance Task (AAT)) towards emotional and social stimuli and the role of 5-HT2A receptor in these effects. METHODS: Twenty healthy recreational users entered a 2 × 2, placebo-controlled, within-subject study with ketanserin (40 mg) as pre-treatment and MDMA (75 mg) as treatment. Behavioural (PAST, AAT) measures were conducted 90 min after treatment with MDMA, respectively, 120 min after ketanserin. Self-report mood measures and oxytocin concentrations were taken at baseline and before and after behavioural tests. RESULTS: Findings showed that MDMA reduced arousal elicited by negative sounds. This effect was counteracted by ketanserin pre-treatment, indicating involvement of the 5-HT2 receptor in this process. MDMA did not seem to induce a bias towards emotional and social stimuli. It increased positive and negative mood ratings and elevated oxytocin plasma concentrations. The reduction in arousal levels when listening to negative sounds was not related to the elevated subjective arousal. CONCLUSION: It is suggested that this decrease in arousal to negative stimuli reflects potentially a lowering of defences, a process that might play a role in the therapeutic process.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Psychopharmacology (Berl). 2017
dc.rights © The Author(s) 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title MDMA-induced indifference to negative sounds is mediated by the 5-HT2A receptor
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1007/s00213-017-4699-1
dc.subject.keyword 5-HT2A receptor
dc.subject.keyword Arousal
dc.subject.keyword Cognitive bias
dc.subject.keyword Ketanserin
dc.subject.keyword MDMA
dc.subject.keyword Oxytocin
dc.subject.keyword Sound processing
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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