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Prognostic impact of circulating plasma cells in patients with multiple myeloma: implications for plasma cell leukemia definition

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dc.contributor.author Granell, Miquel
dc.contributor.author Calvo Gonzalo, Xavier
dc.contributor.author Garcia-Guiñón, Antoni
dc.contributor.author Escoda, Lourdes
dc.contributor.author Abella Monreal, Eugenia
dc.contributor.author Martínez, Clara M.
dc.contributor.author Teixidó, Montserrat
dc.contributor.author Gimenez, Mª Teresa
dc.contributor.author Senín Magan, Maria Alicia
dc.contributor.author Sanz, Patricia
dc.contributor.author Campoy, Desirée
dc.contributor.author Vicent, Ana
dc.contributor.author Arenillas Rocha, Leonor
dc.contributor.author Rosiñol, Laura
dc.contributor.author Sierra, Jorge
dc.contributor.author Blade, Joan
dc.contributor.author Fernández de Larrea, Carlos
dc.contributor.author GEMMAC (Grup per l’estudi del mieloma i l’amiloïdosi de Catalunya)
dc.date.accessioned 2018-01-17T08:00:19Z
dc.date.available 2018-01-17T08:00:19Z
dc.date.issued 2017
dc.identifier.citation Granell M, Calvo X, Garcia-Guiñón A, Escoda L, Abella E, Martínez CM. Et al. Prognostic impact of circulating plasma cells in patients with multiple myeloma: implications for plasma cell leukemia definition. Haematologica. 2017 Jun;102(6):1099-1104. DOI: 10.3324/haematol.2016.158303
dc.identifier.issn 0390-6078
dc.identifier.uri http://hdl.handle.net/10230/33650
dc.description.abstract The presence of circulating plasma cells in patients with multiple myeloma is considered a marker for highly proliferative disease. In the study herein, the impact of circulating plasma cells assessed by cytology on survival of patients with multiple myeloma was analyzed. Wright-Giemsa stained peripheral blood smears of 482 patients with newly diagnosed myeloma or plasma cell leukemia were reviewed and patients were classified into 4 categories according to the percentage of circulating plasma cells: 0%, 1-4%, 5-20%, and plasma cell leukemia with the following frequencies: 382 (79.2%), 83 (17.2%), 12 (2.5%) and 5 (1.0%), respectively. Median overall survival according to the circulating plasma cells group was 47, 50, 6 and 14 months, respectively. At multivariate analysis, the presence of 5 to 20% circulating plasma cells was associated with a worse overall survival (relative risk 4.9, 95% CI 2.6-9.3) independently of age, creatinine, the Durie-Salmon system stage and the International Staging System (ISS) stage. Patients with ≥5% circulating plasma cells had lower platelet counts (median 86×109/L vs 214×109/L, P<0.0001) and higher bone marrow plasma cells (median 53% vs 36%, P=0.004). The presence of ≥5% circulating plasma cells in patients with multiple myeloma has a similar adverse prognostic impact as plasma cell leukemia.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Ferrata Storti Foundation
dc.relation.ispartof Haematologica. 2017 Jun;102(6):1099-104
dc.rights Material published in Haematologica is covered by copyright. All rights are reserved to the Ferrata Storti Foundation. Use of published material is allowed under the following terms and conditions: https://creativecommons.org/licenses/by-nc/4.0/legalcode. Copies of published material are allowed for personal or internal use. Sharing published material for non-commercial purposes is subject to the following conditions: https://creativecommons.org/licenses/by-nc/4.0/legalcode, sect. 3. Reproducing and sharing published material for commercial purposes is not allowed without permission in writing from the publisher.
dc.subject.other Leucèmia
dc.subject.other Càncer -- Aspectes genètics
dc.title Prognostic impact of circulating plasma cells in patients with multiple myeloma: implications for plasma cell leukemia definition
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3324/haematol.2016.158303
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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