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Mediterranean diet improves high-density lipoprotein function in high-cardiovascular-risk Individuals: a randomized controlled trial

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dc.contributor.author Hernáez, Álvaro
dc.contributor.author Castañer, Olga
dc.contributor.author Elosua Llanos, Roberto
dc.contributor.author Pintó Sala, Xavier
dc.contributor.author Estruch, Ramón
dc.contributor.author Salas Salvadó, Jordi
dc.contributor.author Corella, Dolores
dc.contributor.author Arós, Fernando
dc.contributor.author Serra Majem, Lluís
dc.contributor.author Fiol, Miquel
dc.contributor.author Ortega Calvo, Manuel
dc.contributor.author Ros, Emilio
dc.contributor.author Martínez-González, Miguel A.
dc.contributor.author Torre Fornell, Rafael de la
dc.contributor.author López-Sabater, M. Carmen
dc.contributor.author Fitó Colomer, Montserrat
dc.date.accessioned 2017-12-12T08:16:17Z
dc.date.available 2017-12-12T08:16:17Z
dc.date.issued 2017
dc.identifier.citation Hernáez Á, Castañer O, Elosua R, Pintó X, Estruch R, Salas-Salvadó J et al. Mediterranean diet improves high-density lipoprotein function in high-cardiovascular-risk Individuals: a randomized controlled trial. Circulation. 2017 Feb 14;135(7):633-643. DOI: 10.1161/CIRCULATIONAHA.116.023712
dc.identifier.issn 0009-7322
dc.identifier.uri http://hdl.handle.net/10230/33456
dc.description.abstract BACKGROUND: The biological functions of high-density lipoproteins (HDLs) contribute to explaining the cardioprotective role of the lipoprotein beyond quantitative HDL cholesterol levels. A few small-scale interventions with a single antioxidant have improved some HDL functions. However, to date, no long-term, large-scale, randomized controlled trial has been conducted to assess the effects of an antioxidant-rich dietary pattern (such as a traditional Mediterranean diet [TMD]) on HDL function in humans. METHODS: This study was performed in a random subsample of volunteers from the PREDIMED Study (Prevención con Dieta Mediterránea; n=296) after a 1-year intervention. We compared the effects of 2 TMDs, one enriched with virgin olive oil (TMD-VOO; n=100) and the other enriched with nuts (TMD-Nuts; n=100), with respect to a low-fat control diet (n=96). We assessed the effects of both TMDs on the role of HDL particles on reverse cholesterol transport (cholesterol efflux capacity, HDL ability to esterify cholesterol, and cholesteryl ester transfer protein activity), HDL antioxidant properties (paraoxonase-1 arylesterase activity and total HDL antioxidant capacity on low-density lipoproteins), and HDL vasodilatory capacity (HDL ability to induce the release of nitric oxide in endothelial cells). We also studied the effects of a TMD on several HDL quality-related characteristics (HDL particle oxidation, resistance against oxidative modification, main lipid and protein composition, and size distribution). RESULTS: Both TMDs increased cholesterol efflux capacity relative to baseline (P=0.018 and P=0.013 for TMD-VOO and TMD-Nuts, respectively). The TMD-VOO intervention decreased cholesteryl ester transfer protein activity (relative to baseline, P=0.028) and increased HDL ability to esterify cholesterol, paraoxonase-1 arylesterase activity, and HDL vasodilatory capacity (relative to control, P=0.039, P=0.012, and P=0.026, respectively). Adherence to a TMD induced these beneficial changes by improving HDL oxidative status and composition. The 3 diets increased the percentage of large HDL particles (relative to baseline, P<0.001). CONCLUSIONS: The TMD, especially when enriched with virgin olive oil, improved HDL atheroprotective functions in humans.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher American Hearth Association
dc.rights © American Hearth Association http://dx.doi.org/10.1161/CIRCULATIONAHA.116.023712
dc.subject.other Antioxidants
dc.subject.other Dieta -- Mediterrània, Regió de la
dc.title Mediterranean diet improves high-density lipoprotein function in high-cardiovascular-risk Individuals: a randomized controlled trial
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1161/CIRCULATIONAHA.116.023712
dc.subject.keyword Antioxidant
dc.subject.keyword Diet
dc.subject.keyword Lipids
dc.subject.keyword Lipoproteins
dc.subject.keyword HDL
dc.subject.keyword Randomized controlled trial
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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