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Prevalence of cardiovascular risk factors in people with epilepsy

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dc.contributor.author Vivanco Hidalgo, Rosa María
dc.contributor.author Gomez, Alejandra
dc.contributor.author Moreira Villanueva, Antía
dc.contributor.author Díez, Laura
dc.contributor.author Elosua Llanos, Roberto
dc.contributor.author Roquer, Jaume
dc.date.accessioned 2017-11-27T08:41:52Z
dc.date.available 2017-11-27T08:41:52Z
dc.date.issued 2016
dc.identifier.citation Vivanco-Hidalgo RM, Gomez A, Moreira A, Díez L, Elosua R, Roquer J. Prevalence of cardiovascular risk factors in people with epilepsy. Brain Behav. 2016 Dec 20;7(2):e00618. DOI: 10.1002/brb3.618
dc.identifier.issn 2162-3279
dc.identifier.uri http://hdl.handle.net/10230/33337
dc.description.abstract OBJECTIVES: Epilepsy has been associated with cardiovascular comorbidity. This study aimed to assess the potential association between cardiovascular risk factors (CRFs), antiepileptic drugs (AEDs), and etiology. MATERIAL AND METHODS: A single-center retrospective epilepsy cohort from the decade of 2004-2013 was assessed. Poisson regression models with robust variance were estimated to obtain CRF prevalence ratios (PR) according to AED prescription and etiology. RESULTS: After excluding patients in the monotherapy group with vascular etiology or previous cardiovascular events, in the remaining 400 patients, enzyme-inducer AEDs (EIAEDs), especially phenytoin (PHT), were associated with higher prevalence of dyslipidemia (PRa 1.77, p < .05), compared to valproic acid. No etiology was associated with higher prevalence of any CRF. CONCLUSIONS: Patients treated with EIAEDs, especially PHT, had higher prevalence of dyslipidemia.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Wiley
dc.rights Copyright © 2016 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the https://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
dc.subject.other Epilèpsia
dc.subject.other Cor -- Malalties
dc.title Prevalence of cardiovascular risk factors in people with epilepsy
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1002/brb3.618
dc.subject.keyword Antiepileptic drugs
dc.subject.keyword Cardiovascular risk factors
dc.subject.keyword Comorbidity
dc.subject.keyword Epilepsy
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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