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Recent historical migrations have shaped the gene pool of arabs and berbers in North Africa

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dc.contributor.author Arauna, Lara R
dc.contributor.author Mendoza Revilla, Javier
dc.contributor.author Mas Sandoval, Àlex, 1989-
dc.contributor.author Izaabel, Hassan
dc.contributor.author Bekada, Asmahan
dc.contributor.author Benhamamouch, Soraya
dc.contributor.author Fadhlaoui-Zid, Karima
dc.contributor.author Zalloua, Pierre A.
dc.contributor.author Hellenthal, Garrett
dc.contributor.author Comas, David, 1969-
dc.date.accessioned 2017-11-08T16:42:47Z
dc.date.available 2017-11-08T16:42:47Z
dc.date.issued 2017
dc.identifier.citation Arauna LR, Mendoza-Revilla J, Mas-Sandoval A, Izaabel H, Bekada A, Benhamamouch S et al. Recent historical migrations have shaped the gene pool of arabs and berbers in North Africa. Mol Biol Evol. 2017 Feb 1;34(2):318-29. DOI: 10.1093/molbev/msw218
dc.identifier.issn 0737-4038
dc.identifier.uri http://hdl.handle.net/10230/33178
dc.description.abstract North Africa is characterized by its diverse cultural and linguistic groups and its genetic heterogeneity. Genomic data has shown an amalgam of components mixed since pre-Holocean times. Though no differences have been found in uniparental and classical markers between Berbers and Arabs, the two main ethnic groups in the region, the scanty genomic data available have highlighted the singularity of Berbers. We characterize the genetic heterogeneity of North African groups, focusing on the putative differences of Berbers and Arabs, and estimate migration dates. We analyze genome-wide autosomal data in five Berber and six Arab groups, and compare them to Middle Easterns, sub-Saharans, and Europeans. Haplotype-based methods show a lack of correlation between geographical and genetic populations, and a high degree of genetic heterogeneity, without strong differences between Berbers and Arabs. Berbers enclose genetically diverse groups, from isolated endogamous groups with high autochthonous component frequencies, large homozygosity runs and low effective population sizes, to admixed groups with high frequencies of sub-Saharan and Middle Eastern components. Admixture time estimates show a complex pattern of recent historical migrations, with a peak around the 7th century C.E. coincident with the Arabization of the region; sub-Saharan migrations since the 1st century B.C. in agreement with Roman slave trade; and a strong migration in the 17th century C.E., coincident with a huge impact of the trans-Atlantic and trans-Saharan trade of sub-Saharan slaves in the Modern Era. The genetic complexity found should be taken into account when selecting reference groups in population genetics and biomedical studies.
dc.description.sponsorship This work was supported by the Spanish MINECO grants CGL2013-44351-P and the “María de Maeztu” Program for Units of Excellence in R&D (MDM-2014-0370); and the Generalitat de Catalunya grant 2014SGR866.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartof Molecular Biology and Evolution. 2017 Feb 1;34(2):318-29
dc.rights © The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Recent historical migrations have shaped the gene pool of arabs and berbers in North Africa
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1093/molbev/msw218
dc.subject.keyword Population genetics
dc.subject.keyword North Africa
dc.subject.keyword Genome wide SNPs
dc.subject.keyword Berbers
dc.subject.keyword Haplotype
dc.subject.keyword Admixture
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/CGL2013-44351-P
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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