In the human brain, spontaneous activity during resting state consists of rapid transitions between
functional network states over time but the underlying mechanisms are not understood. We use
connectome based computational brain network modeling to reveal fundamental principles of
how the human brain generates large-scale activity observable by noninvasive neuroimaging. We
used structural and functional neuroimaging data to construct whole- brain models. With this novel
approach, we reveal ...
In the human brain, spontaneous activity during resting state consists of rapid transitions between
functional network states over time but the underlying mechanisms are not understood. We use
connectome based computational brain network modeling to reveal fundamental principles of
how the human brain generates large-scale activity observable by noninvasive neuroimaging. We
used structural and functional neuroimaging data to construct whole- brain models. With this novel
approach, we reveal that the human brain during resting state operates at maximum metastability,
i.e. in a state of maximum network switching. In addition, we investigate cortical heterogeneity across
areas. Optimization of the spectral characteristics of each local brain region revealed the dynamical
cortical core of the human brain, which is driving the activity of the rest of the whole brain. Brain
network modelling goes beyond correlational neuroimaging analysis and reveals non-trivial network
mechanisms underlying non-invasive observations. Our novel findings significantly pertain to the
important role of computational connectomics in understanding principles of brain function.
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