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dc.contributor.author | Wurth, Laurence |
dc.contributor.author | Papasaikas, Panagiotis |
dc.contributor.author | Olmeda, David |
dc.contributor.author | Bley, Nadine |
dc.contributor.author | Calvo, Guadalupe T. |
dc.contributor.author | Guerrero Jijon, Santiago Xavier |
dc.contributor.author | Cerezo-Wallis, Daniela |
dc.contributor.author | Martínez-Useros, Javier |
dc.contributor.author | García-Fernández, María |
dc.contributor.author | Hüttelmaier, Stefan |
dc.contributor.author | Soengas, María S. |
dc.contributor.author | Gebauer, Fátima |
dc.date.accessioned | 2017-05-26T08:38:17Z |
dc.date.issued | 2016 |
dc.identifier.citation | Wurth L, Papasaikas P, Olmeda D, Bley N, Calvo GT, Guerrero S et al. UNR/CSDE1 drives a post-transcriptional program to promote melanoma invasion and metastasis. Cancer Cell. 2016 Nov 14;30(5):694-707. DOI: 10.1016/j.ccell.2016.10.004 |
dc.identifier.issn | 1535-6108 |
dc.identifier.uri | http://hdl.handle.net/10230/32171 |
dc.description.abstract | RNA binding proteins (RBPs) modulate cancer progression through poorly understood mechanisms. Here we show that the RBP UNR/CSDE1 is overexpressed in melanoma tumors and promotes invasion and metastasis. iCLIP sequencing, RNA sequencing, and ribosome profiling combined with in silico studies unveiled sets of pro-metastatic factors coordinately regulated by UNR as part of RNA regulons. In addition to RNA steady-state levels, UNR was found to control many of its targets at the level of translation elongation/termination. Key pro-oncogenic targets of UNR included VIM and RAC1, as validated by loss- and gain-of-function studies. Our results identify UNR as an oncogenic modulator of melanoma progression, unravel the underlying molecular mechanisms, and identify potential targets for this therapeutically challenging malignancy. |
dc.description.sponsorship | L.W. was supported by the Fonds National de la Recherche, Luxembourg, and cofunded by the Marie Curie Actions of the European Commission (FP7-COFUND) (Project Code 1072489). M.G.-F. was supported by a Juan de la Cierva fellowship from the Spanish Ministry of Economy and Competitiveness (MINECO). This work was supported by MINECO and the European Regional Development Fund (ERDF) under grant BFU2012-37135 and BFU2015-68741 to F.G., and Consolider CSD2009-00080 and TV’13-20131430 (Marató de TV3) grants to F.G. and M.S.S. We acknowledge support of the Spanish Ministry of Economy and Competitiveness, Centro de Excelencia Severo Ochoa 2013–2017, SEV-2012-0208 (to CRG) and SEV-2011-0191 (to CNIO) |
dc.format.mimetype | application/pdf |
dc.language.iso | eng |
dc.publisher | Elsevier |
dc.relation.ispartof | Cancer Cell. 2016 Nov 14;30(5):694-707 |
dc.rights | © Elsevier http://dx.doi.org/10.1016/j.ccell.2016.10.004 |
dc.subject.other | Melanoma |
dc.subject.other | Metàstasi |
dc.title | UNR/CSDE1 drives a post-transcriptional program to promote melanoma invasion and metastasis |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | http://dx.doi.org/10.1016/j.ccell.2016.10.004 |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/1072489 |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/3PN/BFU2012-37135 |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/1PE/BFU2015-68741 |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/3PN/CSD2009-00080 |
dc.rights.accessRights | info:eu-repo/semantics/openAccess |
dc.type.version | info:eu-repo/semantics/acceptedVersion |