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dc.contributor.author | Payer, Bernhard |
dc.date.accessioned | 2017-05-22T11:24:28Z |
dc.date.issued | 2016 |
dc.identifier.citation | Payer B. Developmental regulation of X-chromosome inactivation. Semin Cell Dev Biol. 2016 Aug;56:88-99. DOI: 10.1016/j.semcdb.2016.04.014 |
dc.identifier.issn | 1084-9521 |
dc.identifier.uri | http://hdl.handle.net/10230/32141 |
dc.description.abstract | With the emergence of sex-determination by sex chromosomes, which differ in composition and number between males and females, appeared the need to equalize X-chromosomal gene dosage between the sexes. Mammals have devised the strategy of X-chromosome inactivation (XCI), in which one of the two X-chromosomes is rendered transcriptionally silent in females. In the mouse, the best-studied model organism with respect to XCI, this inactivation process occurs in different forms, imprinted and random, interspersed by periods of X-chromosome reactivation (XCR), which is needed to switch between the different modes of XCI. In this review, I describe the recent advances with respect to the developmental control of XCI and XCR and in particular their link to differentiation and pluripotency. Furthermore, I review the mechanisms, which influence the timing and choice, with which one of the two X-chromosomes is chosen for inactivation during random XCI. This has an impact on how females are mosaics with regard to which X-chromosome is active in different cells, which has implications on the severity of diseases caused by X-linked mutations. |
dc.description.sponsorship | The work was supported by the Spanish Ministry of Economy and Competitiveness,'Centro de Excelencia Severo Ochoa 2013–2017', SEV-2012-0208 and for a Plan Estatal Grant to B.P. (BFU2014-55275-P) |
dc.format.mimetype | application/pdf |
dc.language.iso | eng |
dc.publisher | Elsevier |
dc.relation.ispartof | Seminars in Cell and Developmental Biology. 2016 Aug;56:88-99 |
dc.rights | © Elsevier http://dx.doi.org/10.1016/j.semcdb.2016.04.014 |
dc.subject.other | Cromosoma X |
dc.subject.other | Epigenètica |
dc.subject.other | RNA |
dc.title | Developmental regulation of X-chromosome inactivation |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | http://dx.doi.org/10.1016/j.semcdb.2016.04.014 |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/1PE/BFU2014-55275-P |
dc.rights.accessRights | info:eu-repo/semantics/openAccess |
dc.type.version | info:eu-repo/semantics/acceptedVersion |