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Anatomically realistic simulations of liver ablation by irreversible electroporation: impact of blood vessels on ablation volumes and undertreatment

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dc.contributor.author Ivorra Cano, Antoni, 1974-
dc.contributor.author Qasrawi, Radwan Fayez Hasan
dc.contributor.author Silve, Louis Charles Arthur
dc.contributor.author Burdío Pinilla, Fernando
dc.contributor.author Abdeen, Ziad
dc.date.accessioned 2017-05-16T08:18:49Z
dc.date.available 2017-05-16T08:18:49Z
dc.date.issued 2017
dc.identifier.citation Qasrawi R, Silve L, Burdío F, Abdeen Z, Ivorra A. Anatomically realistic simulations of liver ablation by irreversible electroporation: impact of blood vessels on ablation volumes and undertreatment. Technol Cancer Res Treat. Forthcoming 2017. 10 p. DOI: 10.1177/1533034616687477
dc.identifier.issn 1533-0346
dc.identifier.uri http://hdl.handle.net/10230/32128
dc.description.abstract Irreversible electroporation is a novel tissue ablation technique which entails delivering intense electrical pulses to target tissue, hence producing fatal defects in the cell membrane. The present study numerically analyzes the potential impact of liver blood vessels on ablation by irreversible electroporation because of their influence on the electric field distribution. An anatomically realistic computer model of the liver and its vasculature within an abdominal section was employed, and blood vessels down to 0.4 mm in diameter were considered. In this model, the electric field distribution was simulated in a large series of scenarios (N = 576) corresponding to plausible percutaneous irreversible electroporation treatments by needle electrode pairs. These modeled treatments were relatively superficial (maximum penetration depth of the electrode within the liver = 26 mm) and it was ensured that the electrodes did not penetrate the vessels nor were in contact with them. In terms of total ablation volume, the maximum deviation caused by the presence of the vessels was 6%, which could be considered negligible compared to the impact by other sources of uncertainty. Sublethal field magnitudes were noticed around vessels covering volumes of up to 228 mm3. If in this model the blood was substituted by a liquid with a low electrical conductivity (0.1 S/m), the maximum volume covered by sublethal field magnitudes was 3.7 mm3 and almost no sublethal regions were observable. We conclude that undertreatment around blood vessels may occur in current liver ablation procedures by irreversible electroporation. Infusion of isotonic low conductivity liquids into the liver vasculature could prevent this risk.
dc.description.sponsorship This work received financial support from the Spanish Government through grants TEC2010-17285, TEC2011-27133-C02, and TEC2014-52383-C3 (TEC2014-52383-C3-2) and from the European Commission through the Marie Curie IRG grant “TAMIVIVE” 256376.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher SAGE Publications
dc.relation.ispartof Technology in Cancer Research & Treatment. Forthcoming 2017. 10 p.
dc.rights This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
dc.rights.uri http://www.creativecommons.org/licenses/by-nc/3.0/
dc.title Anatomically realistic simulations of liver ablation by irreversible electroporation: impact of blood vessels on ablation volumes and undertreatment
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1177/1533034616687477
dc.subject.keyword Irreversible electroporation
dc.subject.keyword Liver
dc.subject.keyword Conductivity
dc.subject.keyword Numerical modeling
dc.subject.keyword Blood vessels
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/256376
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/TEC2010-17285
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/TEC2011-27133-C02
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/TEC2014-52383-C3
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/TEC2014-52383-C3-2
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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