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Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story

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dc.contributor.author Bousquet, Jean
dc.contributor.author Antó i Boqué, Josep Maria
dc.contributor.author Sunyer Deu, Jordi
dc.contributor.author Melén, Erik
dc.contributor.author Benet, Marta
dc.contributor.author Basagaña Flores, Xavier
dc.contributor.author Torrent Quetglas, Maties
dc.contributor.author Xu, Cheng-Jian
dc.date.accessioned 2017-03-29T10:46:43Z
dc.date.available 2017-03-29T10:46:43Z
dc.date.issued 2016
dc.identifier.citation Bousquet J, Anto JM, Akdis M, Auffray C, Keil T, Momas I et al. Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story. Allergy. 2016;71(11):1513-25. DOI: 10.1111/all.12880
dc.identifier.issn 0105-4538
dc.identifier.uri http://hdl.handle.net/10230/28321
dc.description.abstract MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010–2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDALL data of precisely phenotyped children followed in 14 birth cohorts spread across Europe were combined with systems biology (omics, IgE measurement using microarrays) and environmental data. Multimorbidity in the same child is more common than expected by chance alone, suggesting that these diseases share causal mechanisms irrespective of IgE sensitization. IgE sensitization should be considered differently in monosensitized and polysensitized individuals. Allergic multimorbidities and IgE polysensitization are often associated with the persistence or severity of allergic diseases. Environmental exposures are relevant for the development of allergy-related diseases. To complement the population-based studies in children, MeDALL included mechanistic experimental animal studies and in vitro studies in humans. The integration of multimorbidities and polysensitization has resulted in a new classification framework of allergic diseases that could help to improve the understanding of genetic and epigenetic mechanisms of allergy as well as to better manage allergic diseases. Ethics and gender were considered. MeDALL has deployed translational activities within the EU agenda.
dc.description.sponsorship Mechanisms of the Development of ALL ergy; EU FP 7‐CP ‐IP ; Project No: 261357; 2010–2015
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartof Allergy. 2016;71(11):1513-25
dc.rights © 2016 The Authors. Allergy Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1111/all.12880
dc.subject.keyword Asthma
dc.subject.keyword IgE
dc.subject.keyword Multimorbidity
dc.subject.keyword Polysensitization
dc.subject.keyword Rhinitis
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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