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Lokiarchaeota Marks the Transition between the Archaeal and Eukaryotic Selenocysteine Encoding Systems.

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dc.contributor.author Mariotti, Marco, 1984-
dc.contributor.author Lobanov, Alexei V.
dc.contributor.author Manta, Bruno
dc.contributor.author Santesmasses Ruiz, Didac, 1978-
dc.contributor.author Bofill Pumarola, Andreu
dc.contributor.author Guigó Serra, Roderic
dc.contributor.author Gabaldón Estevan, Juan Antonio, 1973-
dc.contributor.author Gladyshev, Vadim N.
dc.date.accessioned 2017-01-09T10:40:11Z
dc.date.available 2017-01-09T10:40:11Z
dc.date.issued 2016
dc.identifier.citation Mariotti M, Lobanov AV, Manta B, Santesmasses D, Bofill A, Guigó R. et al. Lokiarchaeota Marks the Transition between the Archaeal and Eukaryotic Selenocysteine Encoding Systems. Mol Biol Evol. 2016 Sep;33(9):2441-53. doi: 10.1093/molbev/msw122
dc.identifier.issn 0737-4038
dc.identifier.uri http://hdl.handle.net/10230/27853
dc.description.abstract Selenocysteine (Sec) is the 21st amino acid in the genetic code, inserted in response to UGA codons with the help of RNA structures, the SEC Insertion Sequence (SECIS) elements. The three domains of life feature distinct strategies for Sec insertion in proteins and its utilization. While bacteria and archaea possess similar sets of selenoproteins, Sec biosynthesis is more similar among archaea and eukaryotes. However, SECIS elements are completely different in the three domains of life. Here, we analyze the archaeon Lokiarchaeota that resolves the relationships among Sec insertion systems. This organism has selenoproteins representing five protein families, three of which have multiple Sec residues. Remarkably, these archaeal selenoprotein genes possess conserved RNA structures that strongly resemble the eukaryotic SECIS element, including key eukaryotic protein-binding sites. These structures also share similarity with the SECIS element in archaeal selenoprotein VhuD, suggesting a relation of direct descent. These results identify Lokiarchaeota as an intermediate form between the archaeal and eukaryotic Sec-encoding systems and clarify the evolution of the Sec insertion system.
dc.description.sponsorship This study was supported by NIH GM061603, GM065205 and CA080946. B.M. is partly supported by The Pew Charitable Trust postdoctoral fellow program.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Oxford University Press
dc.rights © The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
dc.rights.uri https://creativecommons.org/licenses/by-nc/4.0/
dc.subject.other Codi genètic
dc.subject.other Genètica
dc.title Lokiarchaeota Marks the Transition between the Archaeal and Eukaryotic Selenocysteine Encoding Systems.
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1093/molbev/msw122
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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