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Modulation of irisin and physical activity on executive functions in obesity and morbid obesity

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dc.contributor.author Fagundo, Ana B.
dc.contributor.author Torre Fornell, Rafael de la
dc.contributor.author Fernández Aranda, Fernando
dc.date.accessioned 2016-12-07T12:31:21Z
dc.date.available 2016-12-07T12:31:21Z
dc.date.issued 2016
dc.identifier.citation Fagundo AB, Jiménez-Murcia S, Giner-Bartolomé C, Agüera Z, Sauchelli S, Pardo M. et al. Modulation of irisin and physical activity on executive functions in obesity and morbid obesity. Sci Rep. 2016 Aug 1;6:30820. doi: 10.1038/srep30820
dc.identifier.issn 2045-2322
dc.identifier.uri http://hdl.handle.net/10230/27715
dc.description.abstract Whether the executive profile is different between obesity (OB) and morbid obesity (MO) remains unclear. Recent evidence suggests that physical activity (PA) can act as a cognitive enhancer. Irisin is a recently discovered hormone associated with some of the positive effects of PA. The objective of the study was to investigate the executive profile in OB and MO, and to explore the role of PA and irisin. 114 participants were included (21 OB, 44 MO and 49 healthy controls-HC) in the study and assessed with the Wisconsin Card Sorting Test, Stroop Color and Word Test, and Iowa Gambling Task. All participants were female, aged between 18 and 60 years. Results showed a similar dysfunctional profile on decision making in OB and MO compared with HC. Thus, no specific neuropsychological profiles between OB and MO can be clearly observed in our sample. However, a negative correlation was found between irisin and executive functioning. These results demonstrate a specific executive profile in OB and a relevant and negative modulation of irisin on executive functioning. Although irisin might be a promising target for the treatment of obesity, its effects on cognition might be considered when thinking about its therapeutic use.
dc.description.sponsorship This work was supported by Instituto de Salud Carlos III (ISCIII)[FIS PI14/00290 and European Regional Development Fund (ERDF)-“a way to Build Europe”-// FONDOS FEDER “una manera de hacer Europa”] AGAUR (2009SGR1554, 2009SGR718); ABF was supported by Ministerio de Ciencia e Innovación Subprograma Juan de la Cierva (JCI-2011-09248); CGB was supported by Ayudas Predoctorales de Formación en Investigación en Salud-PFIS (FI12/00470). ABC is funded by the ISCIII through a research contract “Sara Borrell” (C09/00365). MP is a Miguel Servet Fellow (ISCIII/SERGAS). JCFG is recipient of a research contract from Servicio Andaluz de Salud (SAS) (B-0033-2014). CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn) and CIBER Salud Mental (CIBERsam), are supported by ISCIII.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Nature Publishing Group
dc.relation.ispartof Scientific Reports. 2016 Aug 1;6:30820
dc.rights © 2016, The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject.other Obesitat
dc.subject.other Exercici -- Aspectes fisiològics
dc.subject.other Obesitat mòrbida
dc.title Modulation of irisin and physical activity on executive functions in obesity and morbid obesity
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1038/srep30820
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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