Welcome to the UPF Digital Repository

Long-Term Prediction of the Demand of Colonoscopies Generated by a Population-Based Colorectal Cancer Screening Program.

Show simple item record

dc.contributor.author Comas Serrano, Mercè
dc.contributor.author Mendivil, Joan
dc.contributor.author Andreu García, Montserrat
dc.contributor.author Hernández Rodríguez, Cristina
dc.contributor.author Castells, Xavier
dc.date.accessioned 2016-11-22T12:35:19Z
dc.date.available 2016-11-22T12:35:19Z
dc.date.issued 2016
dc.identifier.citation Comas M, Mendivil J, Andreu M, Hernández C, Castells X. Long-Term Prediction of the Demand of Colonoscopies Generated by a Population-Based Colorectal Cancer Screening Program. PLoS One. 2016 Oct 12;11(10):e0164666. doi: 10.1371/journal.pone.0164666
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10230/27564
dc.description.abstract OBJECTIVE: To estimate the long-term need for colonoscopies after a positive fecal immunochemical test (FIT) and post-polypectomy surveillance in the context of a population-based colorectal cancer (CRC) screening program. METHODS: A discrete-event simulation model was built to reproduce the process of CRC screening and post-polypectomy surveillance following European guidelines in a population of 100,000 men and women aged 50-69 years over a 20-year period. Screening consisted of biennial FIT and colonoscopy in participants with positive results. The model was mainly fed using data from the first and second rounds of a Spanish program (2010-2013). Data on post-polypectomy surveillance results were obtained from the literature. A probabilistic multivariate sensitivity analysis was performed on the effect of participation, FIT positivity, and adherence to surveillance colonoscopies. The main outcome variables were the number of colonoscopies after a positive FIT, surveillance colonoscopies, and the overall number of colonoscopies. RESULTS: An average yearly number of 1,200 colonoscopies after a positive FIT were predicted per 100,000 inhabitants with a slight increase to 1,400 at the end of the 20-year period. Surveillance colonoscopies increased to an average of 1,000 per 100,000 inhabitants in the long-term, showing certain stabilization in the last years of the 20-year simulation horizon. The results were highly sensitive to FIT positivity. ONCLUSIONS: Implementing a population-based CRC screening program will increase the demand for colonoscopies, which is expected to double in 20 years, mainly due to an increase in surveillance colonoscopies.
dc.description.sponsorship Financial support for this study was provided to MC by grant number PI07/90357 from Instituto de Salud Carlos III-FEDER (www.isciii.es/) and number AP94422011 from Fundación Mutua Madrileña (www.fundacionmutua.es/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Roche Diagnostics International Ltd., a commercial company, provided support in the form of salaries for JM, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific role of this author is articulated in the ‘author contributions’ section.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartof PLoS One. 2016 Oct 12;11(10):e0164666
dc.rights 2016 Comas et al/nThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject.other Còlon -- Càncer
dc.subject.other Colonoscòpia
dc.title Long-Term Prediction of the Demand of Colonoscopies Generated by a Population-Based Colorectal Cancer Screening Program.
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0164666
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account

Statistics

In collaboration with Compliant to Partaking