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Demonstration of 2 mm thick microcontrolled injectable stimulators based on rectification of high frequency current bursts

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dc.contributor.author Becerra-Fajardo, Laura
dc.contributor.author Schmidbauer, Marieluise
dc.contributor.author Ivorra Cano, Antoni, 1974-
dc.date.accessioned 2016-11-17T11:27:03Z
dc.date.available 2016-11-17T11:27:03Z
dc.date.issued 2016
dc.identifier.citation Becerra-Fajardo L, Schmidbauer M, Ivorra A. Demonstration of 2 mm thick microcontrolled injectable stimulators based on rectification of high frequency current bursts. IEEE Trans Neural Syst Rehabil Eng. 2016;PP(99):1-10. DOI: 10.1109/TNSRE.2016.2623483
dc.identifier.issn 1534-4320
dc.identifier.uri http://hdl.handle.net/10230/27530
dc.description.abstract Existing implantable stimulators use powering approaches that result in stiff and bulky systems or result in systems incapable of producing the current magnitudes required for neuromuscular stimulation. This hampers their use in neuroprostheses for paralysis. We previously demonstrated an electrical stimulation method based on electronic rectification of high frequency (HF) current bursts. The implants act as rectifiers of HF current that flows through the tissues by galvanic coupling, transforming this current into low frequency current capable of performing neuromuscular stimulation. Here we developed 2 mm thick, semi-rigid, injectable and addressable stimulators made of off-the-shelf components and based on this method. The devices were tested in vitro to illustrate how they are powered by galvanic coupling. In addition they were tried in an animal model to demonstrate their ability to perform controlled electrical stimulation. The implants were deployed by injection into two antagonist muscles of an anesthetized rabbit and were addressed resulting in independent isometric contractions. Low frequency currents of 2 mA were delivered by the implants. The HF currents are safe in terms of unwanted electrostimulation and tissue heating according to standards. This indicates that the proposed electrical stimulation method will allow unprecedented levels of miniaturization for neuroprostheses.
dc.description.sponsorship LBF‘s research is supported by a PRC fellowship from the UPF. AI‘s research was supported by a Marie Curie grant (IRG 256376) from the European Commission.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Institute of Electrical and Electronics Engineers (IEEE)
dc.relation.ispartof IEEE Engineering in Medicine and Biology Society. 2016;PP(99):1-10.
dc.rights © 2016 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works./nThe final published article can be found at http://ieeexplore.ieee.org/document/7726054/
dc.title Demonstration of 2 mm thick microcontrolled injectable stimulators based on rectification of high frequency current bursts
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1109/TNSRE.2016.2623483
dc.subject.keyword Galvanic coupling
dc.subject.keyword Microstimulator
dc.subject.keyword Neuroprostheses
dc.subject.keyword Rectifiers
dc.subject.keyword Rectifiers
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/256376
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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