Welcome to the UPF Digital Repository

Ausencia de correlación entre marcadores de inflamación pulmonar y sistémica en pacientes con enfermedad pulmonar obstructiva crónica: un análisis bi-compartimental simultáneo

Show simple item record

dc.contributor.author Núñez, Belén
dc.contributor.author Sauleda Roig, Jaume
dc.contributor.author García Aymerich, Judith
dc.contributor.author Noguera, Aina
dc.contributor.author Monsó, Eduard
dc.contributor.author Gómez, Federico P.
dc.contributor.author Barreiro Portela, Esther
dc.contributor.author Marin, Alicia
dc.contributor.author Antó i Boqué, Josep Maria
dc.contributor.author Agustí, Alvar
dc.contributor.author Caracterización Fenotípica y Evolución de la EPOC (PAC-COPD)
dc.date.accessioned 2016-09-08T07:27:00Z
dc.date.issued 2016
dc.identifier.citation Núñez B, Sauleda J, Garcia-Aymerich J, Noguera A, Monsó E, Gómez F. et al. Lack of Correlation Between Pulmonary and Systemic Inflammation Markers in Patients with Chronic Obstructive Pulmonary Disease: A Simultaneous, Two-Compartmental Analysis. Arch Bronconeumol. 2016 Jul;52(7):361-7. doi: 10.1016/j.arbres.2016.01.003
dc.identifier.issn 0300-2896
dc.identifier.uri http://hdl.handle.net/10230/27281
dc.description.abstract INTRODUCTION: The origin of systemic inflammation in chronic obstructive pulmonary disease (COPD) patients remains to be defined, but one of the most widely accepted hypothesis is the 'spill over' of inflammatory mediators from the lung to the circulation. OBJECTIVE: To evaluate the relationship between pulmonary and systemic inflammation in COPD quantifying several inflammatory markers in sputum and serum determined simultaneously. METHODOLOGY: Correlations between various inflammatory variables (TNF-α, IL6, IL8) in sputum and serum were evaluated in 133 patients from the PAC-COPD cohort study. A secondary objective was the evaluation of relationships between inflammatory variables and lung function. RESULTS: Inflammatory markers were clearly higher in sputum than in serum. No significant correlation was found (absolute value, r=0.03-0.24) between inflammatory markers in blood and in sputum. There were no significant associations identified between those markers and lung function variables, such as FEV1, DLCO and PaO2 neither. CONCLUSIONS: We found no correlation between pulmonary and systemic inflammation in patients with stable COPD, suggesting different pathogenic mechanisms.
dc.description.sponsorship Financiado en parte por: Fondo de Investigación Sanitaria (PI020541, PI052082, PI052486, 11/02029, 14/00713,), Ministerio de Salud, España; Agència d’Avaluació de Tecnologia i Recerca Mèdiques (AATRM 035/20/02), Govern de Catalunya; Sociedad Española de Neumología y Cirugía Torácica (SEPAR 2002/137, SEPAR 2013); Fundació Catalana de Pneumologia (FUCAP 2003 Beca Marià Ravà); Red RESPIRA (RTIC C03/11); Red RCESP (RTIC C03/09); Fundació La Marató de TV3 (num. 041110); DURSI (2005SGR00392); y una beca educativa de Novartis Farmacéutica, . CIBERESP y CIBERES están fundadas por el Instituto de Salud Carlos III, Ministerio de Salud, España. Direcció General d´Investigació i desenvolupament tecnològic de la Conselleria d´Innovació, Interior i Justícia de la Comunitat Autònoma de les Illes Balears and Fondos FEDER (Grupos competitivos (PRE-R-22528-2011).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.language.iso spa
dc.publisher Elsevier
dc.rights © Elsevier http://dx.doi.org/10.1016/j.arbres.2016.01.003
dc.subject.other Pulmons -- Malalties obstructives
dc.subject.other Bronquitis
dc.subject.other Citocines
dc.title Ausencia de correlación entre marcadores de inflamación pulmonar y sistémica en pacientes con enfermedad pulmonar obstructiva crónica: un análisis bi-compartimental simultáneo
dc.title.alternative Lack of Correlation Between Pulmonary and Systemic Inflammation Markers in Patients with Chronic Obstructive Pulmonary Disease: A Simultaneous, Two-Compartmental Analysis.
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.arbres.2016.01.003
dc.rights.accessRights info:eu-repo/semantics/embargoedAccess
dc.type.version info:eu-repo/semantics/acceptedVersion
dc.embargo.liftdate 2017-07-31
dc.date.embargoEnd info:eu-repo/date/embargoEnd/2017-07-31


This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account

Statistics

Compliant to Partaking