Welcome to the UPF Digital Repository

In vitro mitomycin C absorption and delivery with different sponge materials used in filtering surgery.

Show simple item record

dc.contributor.author Urbaneja, Diana
dc.contributor.author Morilla-Grasa, Antonio
dc.contributor.author Jiménez, Elisa
dc.contributor.author Montemayor, Judith
dc.contributor.author Marcobal Barbara, Nuria
dc.contributor.author Aragay Suñol, M. Carmen
dc.contributor.author Gurdiel Fernández, Celia
dc.contributor.author Armillas García, Marta
dc.contributor.author Ortiz Sagrista, Pere
dc.contributor.author Antón López, Alfonso
dc.date.accessioned 2016-07-12T11:39:18Z
dc.date.available 2016-07-12T11:39:18Z
dc.date.issued 2016
dc.identifier.citation Urbaneja D, Morilla-Grasa A, Jimenez E, Montemayor J, Marcobal N, Aragay C. et al. In vitro mitomycin C absorption and delivery with different sponge materials used in filtering surgery. Clin Ophthalmol. 2016 Apr 15;10:665-9. doi: 10.2147/OPTH.S101345
dc.identifier.issn 1177-5467
dc.identifier.uri http://hdl.handle.net/10230/27031
dc.description.abstract PURPOSE: The purpose of this study is to evaluate and compare mitomycin C (MMC) absorption and delivery in different materials used in filtering surgery. METHODS: This is an in vitro study comparing polyvinyl alcohol triangular sponges (TS6, TS8), polyvinyl alcohol fluid wicks (EFW), and absorbable gelatin sponges (AGS3, AGS5), from which five different types of transport units were obtained. Seven pieces of sponge of each transport unit type were obtained as follows: two transverse strips were obtained at 6 and 8 mm from the apex of TS and divided into three equal pieces; 4×4 mm pieces of EFW; 3×3 and 5×5 mm pieces of absorbable gelatin sponges were cut. Filter paper was placed on a precision scale (0.01 mg). The seven sponge pieces of each type were weighed three times consecutively in dry and wet states, the latter after immersion for 15 seconds in 0.2 mg/mL MMC. The difference between the weights of the dry and wet filter paper at the end of each measurement sequence was also calculated and considered as an estimate of the amount of mitomycin delivered. RESULTS: The amounts of MMC absorbed by each transport unit were as follows: (mean ± standard deviation) 27.43±5.13 for TS6, 31.91±6.63 for TS8, 15.96±2.23 for EFW, 17.96±2.05 for AGS3, and 33.81±2.05 for AGS5. The amounts of MMC delivered to the filter paper were as follows: 21.70±2.84 for TS6, 23.83±4.03 for TS8, 12.93±1.75 for EFW, 14.69±1.79 for AGS3, and 27.30±1.58 for AGS5. CONCLUSION: Percentage MMC delivered was similar for all materials, but there was a tendency for greater delivery using larger sponges and greater homogeneity in delivery with AGS5. No statistical differences were found in percentage delivered by the different transport materials.
dc.format.mimetype application/pdf
dc.language.iso cat
dc.publisher Dove Medical Press
dc.relation.ispartof Clinical Ophthalmology. 2016 Apr 15;10:665-9
dc.rights 2016 Urbaneja et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.phpand incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
dc.rights.uri https://creativecommons.org/licenses/by-nc/3.0/
dc.subject.other Glaucoma
dc.title In vitro mitomycin C absorption and delivery with different sponge materials used in filtering surgery.
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.2147/OPTH.S101345
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account

Statistics

In collaboration with Compliant to Partaking