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Origin and evolution of metabolic sub-cellular compartmentalization in eukaryotes

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dc.contributor.author Gabaldón Estevan, Juan Antonio, 1973-
dc.contributor.author Pittis, Alexandros, 1982-
dc.date.accessioned 2016-06-08T13:44:32Z
dc.date.available 2016-06-08T13:44:32Z
dc.date.issued 2016
dc.identifier.citation Gabaldón T, Pittis AA. Origin and evolution of metabolic sub-cellular compartmentalization in eukaryotes. Biochimie. 2015; 119(1): 262-268. DOI 10.1016/j.biochi.2015.03.021
dc.identifier.issn 0300-9084
dc.identifier.uri http://hdl.handle.net/10230/26876
dc.description.abstract A high level of subcellular compartmentalization is a hallmark of eukaryotic cells. This intricate internal organization was present already in the common ancestor of all extant eukaryotes, and the determination of the origins and early evolution of the different organelles remains largely elusive. Organellar proteomes are determined through regulated pathways that target proteins produced in the cytosol to their final subcellular destinations. This internal sorting of proteins can vary across different physiological conditions, cell types and lineages. Evolutionary retargeting - the alteration of a subcellular localization of a protein in the course of evolution - has been rampant in eukaryotes and involves any possible combination of organelles. This fact adds another layer of difficulty to the reconstruction of the origins and evolution of organelles. In this review we discuss current themes in relation to the origin and evolution of organellar proteomes. Throughout the text, a special focus is set on the evolution of mitochondrial and peroxisomal proteomes, which are two organelles for which extensive proteomic and evolutionary studies have been performed.
dc.description.sponsorship TG group research is funded in part by a grant from the Spanish ministry of Economy and Competitiveness (BIO2012-37161), a Grant from the Qatar National Research Fund grant (NPRP 5-298-3-086), and a grant from the European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013)/ ERC (Grant Agreement n. ERC-2012-StG-310325).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Biochimie. 2015; 119(1): 262-268
dc.rights © The Authors. Published by Elsevier B.V. /nThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.other Cèl·lules eucariotes
dc.title Origin and evolution of metabolic sub-cellular compartmentalization in eukaryotes
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.biochi.2015.03.021
dc.subject.keyword Compartments
dc.subject.keyword Eukaryotes
dc.subject.keyword Evolution
dc.subject.keyword Organelles
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BIO2012-37161
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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