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Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns

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dc.contributor.author Sánchez Mut, Jose V.
dc.contributor.author Heyn, Holger
dc.contributor.author Vidal, Enrique
dc.contributor.author Moran, Sebastian
dc.contributor.author Sayols, Sergi
dc.contributor.author Delgado Morales, Raul
dc.contributor.author Schultz, Matthew D.
dc.contributor.author Ansoleaga, Belén
dc.contributor.author García Esparcia, Paula
dc.contributor.author Pons Espinal, Meritxell, 1986-
dc.contributor.author Martínez de Lagran, Maía
dc.contributor.author Dopazo, Jose M.
dc.contributor.author Rábano, Alberto
dc.contributor.author Ávila, Jesús
dc.contributor.author Dierssen, Mara
dc.contributor.author Lott, Ira T.
dc.contributor.author Ferrer, Isidre
dc.contributor.author Ecker, Joseph R.
dc.contributor.author Esteller, Manel
dc.date.accessioned 2016-06-03T14:38:50Z
dc.date.available 2016-06-03T14:38:50Z
dc.date.issued 2016
dc.identifier.citation Sanchez-Mut JV, Heyn H, Vidal E, Moran S, Sayols S, Delgado-Morales R et al. Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns. Translational psychiatry. 2016; 6: e718. DOI 10.1038/tp.2015.214
dc.identifier.issn 2158-3188
dc.identifier.uri http://hdl.handle.net/10230/26821
dc.description.abstract Different neurodegenerative disorders often show similar lesions, such as the presence of amyloid plaques, TAU-neurotangles and synuclein inclusions. The genetically inherited forms are rare, so we wondered whether shared epigenetic aberrations, such as those affecting DNA methylation, might also exist. The studied samples were gray matter samples from the prefrontal cortex of control and neurodegenerative disease-associated cases. We performed the DNA methylation analyses of Alzheimer's disease, dementia with Lewy bodies, Parkinson's disease and Alzheimer-like neurodegenerative profile associated with Down's syndrome samples. The DNA methylation landscapes obtained show that neurodegenerative diseases share similar aberrant CpG methylation shifts targeting a defined gene set. Our findings suggest that neurodegenerative disorders might have similar pathogenetic mechanisms that subsequently evolve into different clinical entities. The identified aberrant DNA methylation changes can be used as biomarkers of the disorders and as potential new targets for the development of new therapies.
dc.description.sponsorship This work was supported by the Human Frontiers Science Program (HFSP) Ref. RGP0018/2007-C, the European Community’s RGP0018/2007-C (FP7/2007-2013) under grant agreement PITN-GA-2009-238242—DISCHROM project and grant agreement 278486-DEVELAGE, the Instituto de Salud Carlos III—Ministerio de Sanidad y Consumo Proyecto FIS (Fondo Investigación Sanitaria, Spain) through the E-RARE EuroRETT network, Grants P50-AG16573, HD065160-01 and SAF2007-6-8, the Fondation Lejeune, Botin Foundation, Fundació Agrupació Premi Àmbit Gent Grant and the Cellex Foundation (Catalonia).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Nature Publishing Group
dc.relation.ispartof Translational psychiatry. 2016; 6: e718
dc.rights © Nature Publishing Group. http://www.nature.com/tp/journal/v6/n1/full/tp2015214a.html/nThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.other ADN
dc.subject.other Sistema nerviós Degeneració
dc.title Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1038/tp.2015.214
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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