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Assessment of wall elasticity variations on intraluminal haemodynamics in descending aortic dissections using a lumped-parameter model

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dc.contributor.author Rudenick, Paula A.
dc.contributor.author Bijnens, Bart
dc.contributor.author Segers, Patrick F.
dc.contributor.author García-Dorado, David
dc.contributor.author Evangelista, Arturo
dc.date.accessioned 2016-05-23T12:49:43Z
dc.date.available 2016-05-23T12:49:43Z
dc.date.issued 2015
dc.identifier.citation Rudenick PA, Bijnens BH, Segers P, Garcia-Dorado D, Evangelista A. Assessment of wall elasticity variations on intraluminal haemodynamics in descending aortic dissections using a lumped-parameter model. PLoS ONE. 2015;10(4):e0124011. doi: 10.1371/journal.pone.0124011
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10230/26325
dc.description.abstract Descending aortic dissection (DAD) is associated with high morbidity and mortality rates. Aortic wall stiffness is a variable often altered in DAD patients and potentially involved in long-term outcome. However, its relevance is still mostly unknown. To gain more detailed knowledge of how wall elasticity (compliance) might influence intraluminal haemodynamics in DAD, a lumped-parameter model was developed based on experimental data from a pulsatile hydraulic circuit and validated for 8 clinical scenarios. Next, the variations of intraluminal pressures and flows were assessed as a function of wall elasticity. In comparison with the most rigid-wall case, an increase in elasticity to physiological values was associated with a decrease in systolic and increase in diastolic pressures of up to 33% and 63% respectively, with a subsequent decrease in the pressure wave amplitude of up to 86%. Moreover, it was related to an increase in multidirectional intraluminal flows and transition of behaviour as 2 parallel vessels towards a vessel with a side-chamber. The model supports the extremely important role of wall elasticity as determinant of intraluminal pressures and flow patterns for DAD, and thus, the relevance of considering it during clinical assessment and computational modelling of the disease.
dc.description.sponsorship This study was partially supported by the Subprograma de Proyectos de Investigación en Salud (FIS), Instituto de Salud Carlos III, Spain (ref. PI108/0608, PI11/01709); the Programa de ayudas destinadas a universidades, centros de investigación y fundaciones hospitalarias para la contratación de personal investigador novel (FI-DGR 2011), Spain; and the EU FP7 for research, technological development and demonstration under grant agreement VP2HF (no 611823).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartof PLoS ONE. 2015;10(4):e0124011
dc.rights © 2015 Rudenick et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Assessment of wall elasticity variations on intraluminal haemodynamics in descending aortic dissections using a lumped-parameter model
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0124011
dc.subject.keyword Systolic pressure
dc.subject.keyword Fluid flow
dc.subject.keyword Stiffness
dc.subject.keyword Mathematical models
dc.subject.keyword Catheterization
dc.subject.keyword Flow rate
dc.subject.keyword Aorta
dc.subject.keyword Simulation and modeling
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/611823
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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