GEMC1 is a critical regulator of multiciliated cell differentiation.

Terré, Berta; Piergiovanni, Gabriele; Segura-Bayona, Sandra; Gil Gómez, Gabriel; Youssef, Sameh A.; Attolini, Camille Stephan-Otto; Wilsch-Bräuninger, Michaela; Jung, Carole; Rojas Mendoza, Ana Maria; Marjanovi c, Marko; Knobel, Philip A.; Palenzuela, Lluís; López-Rovira, Teresa; Forrow, Stephen; Huttner, Wieland B.; Valverde, M. A. (Miguel Ángel), 1963-; de Bruin, Alain; Costanzo, Vincenzo; Stracker, Travis

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GEMC1 is a critical regulator of multiciliated cell differentiation.

Document Type: Article

Version: Accepted version

Date: 2016

Name: terre-emj-gemc.pdf

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Citation: Terré B1, Piergiovanni G, Segura-Bayona S, Gil-Gómez G, Youssef SA, Attolini CS. et al. GEMC1 is a critical regulator of multiciliated cell differentiation. EMBO J. 2016 May 2;35(9):942-60. DOI: 10.15252/embj.201592821.

Permanent link: http://hdl.handle.net/10230/26303

Abstract:

The generation of multiciliated cells (MCCs) is required for the proper function of many tissues, including the respiratory tract, brain, and germline. Defects in MCC development have been demonstrated to cause a subclass of mucociliary clearance disorders termed reduced generation of multiple motile cilia (RGMC). To date, only two genes, Multicilin (MCIDAS) and cyclin O (CCNO) have been identified in this disorder in humans.