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Traffic pollution exposure is associated with altered brain connectivity in school children.

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dc.contributor.author Pujol Martí, Jesús, 1981-
dc.contributor.author Martínez-Vilavella, Gerard
dc.contributor.author Macià, Dídac
dc.contributor.author Fenoll, Raquel
dc.contributor.author Álvarez Pedrerol, Mar
dc.contributor.author Rivas, Ioar
dc.contributor.author Forns i Guzman, Joan, 1981-
dc.contributor.author Blanco Hinojo, Laura, 1981-
dc.contributor.author Capellades Font, Jaume
dc.contributor.author Querol, Xavier
dc.contributor.author Deus, Joan
dc.contributor.author Sunyer Deu, Jordi
dc.date.accessioned 2016-05-05T10:42:16Z
dc.date.issued 2016
dc.identifier.citation Pujol J, Martínez-Vilavella G, Macià D, Fenoll R, Alvarez-Pedrerol M, Rivas I. et al. Traffic pollution exposure is associated with altered brain connectivity in school children. Neuroimage. 2016 Apr 1;129:175-84. doi: 10.1016/j.neuroimage.2016.01.036
dc.identifier.issn 1053-8119
dc.identifier.uri http://hdl.handle.net/10230/26247
dc.description.abstract Children are more vulnerable to the effects of environmental elements due to their active developmental processes. Exposure to urban air pollution has been associated with poorer cognitive performance, which is thought to be a result of direct interference with brain maturation. We aimed to assess the extent of such potential effects of urban pollution on child brain maturation using general indicators of vehicle exhaust measured in the school environment and a comprehensive imaging evaluation. A group of 263 children, aged 8 to 12years, underwent MRI to quantify regional brain volumes, tissue composition, myelination, cortical thickness, neural tract architecture, membrane metabolites, functional connectivity in major neural networks and activation/deactivation dynamics during a sensory task. A combined measurement of elemental carbon and NO2 was used as a putative marker of vehicle exhaust. Air pollution exposure was associated with brain changes of a functional nature, with no evident effect on brain anatomy, structure or membrane metabolites. Specifically, a higher content of pollutants was associated with lower functional integration and segregation in key brain networks relevant to both inner mental processes (the default mode network) and stimulus-driven mental operations. Age and performance (motor response speed) both showed the opposite effect to that of pollution, thus indicating that higher exposure is associated with slower brain maturation. In conclusion, urban air pollution appears to adversely affect brain maturation in a critical age with changes specifically concerning the functional domain.
dc.description.sponsorship This work was supported by the European Research Council under the ERC [grant number 268479]—the BREATHE project. The Agency of University and Research Funding Management of the Catalonia Government participated in the context of Research Group SGR2014-1673.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.rights © Elsevier http://dx.doi.org/10.1016/j.neuroimage.2016.01.036
dc.subject.other Aire -- Contaminació
dc.subject.other Infants -- Desenvolupament
dc.title Traffic pollution exposure is associated with altered brain connectivity in school children.
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.neuroimage.2016.01.036
dc.relation.projectID info:eu-repo/grantAgreement/EC (2011 - 2016)/268479
dc.rights.accessRights info:eu-repo/semantics/embargoedAccess
dc.type.version info:eu-repo/semantics/acceptedVersion
dc.embargo.liftdate 2017-04-30
dc.date.embargoEnd info:eu-repo/date/embargoEnd/2017-04-30


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