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Addressing the challenges of pancreatic cancer: future directions for improving outcomes

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dc.contributor.author Hidalgo, Manuel
dc.contributor.author Cascinu, Stefano
dc.contributor.author Kleeff, Jörg
dc.contributor.author Labianca, Roberto
dc.contributor.author Löhr, J. Matthias
dc.contributor.author Neoptolemos, John
dc.contributor.author Real, Francisco X.
dc.contributor.author Van Laethem, Jean-Luc
dc.contributor.author Heinemann, Volker
dc.date.accessioned 2016-04-27T13:06:49Z
dc.date.available 2016-04-27T13:06:49Z
dc.date.issued 2015
dc.identifier.citation Hidalgo M, Cascinu S, Kleeff J, Labianca R, Löhr JM, Neoptolemos J et al. Addressing the challenges of pancreatic cancer: future directions for improving outcomes. Pancreatology. 2015;15(1):8-18. DOI: 10.1016/j.pan.2014.10.001
dc.identifier.issn 1424-3903
dc.identifier.uri http://hdl.handle.net/10230/26187
dc.description.abstract Pancreatic ductal adenocarcinoma (PDAC), which accounts for more than 90% of all pancreatic tumours, is a devastating malignancy with an extremely poor prognosis, as shown by a 1-year survival rate of around 18% for all stages of the disease. The low survival rates associated with PDAC primarily reflect the fact that tumours progress rapidly with few specific symptoms and are thus at an advanced stage at diagnosis in most patients. As a result, there is an urgent need to develop accurate markers of pre-invasive pancreatic neoplasms in order to facilitate prediction of cancer risk and to help diagnose the disease at an earlier stage. However, screening for early diagnosis of prostate cancer remains challenging and identifying a highly accurate, low-cost screening test for early PDAC for use in clinical practice remains an important unmet need. More effective therapies are also crucial in PDAC, since progress in identifying novel therapies has been hampered by the genetic complexity of the disease and treatment remains a major challenge. Presently, the greatest step towards improved treatment efficacy has been made in the field of palliative chemotherapy by introducing FOLFIRINOX (folinic acid, 5-fluorouracil, irinotecan and oxaliplatin) and gemcitabine/nab-paclitaxel. Strategies designed to raise the profile of PDAC in research and clinical practice are a further requirement in order to ensure the best treatment for patients. This article proposes a number of approaches that may help to accelerate progress in treating patients with PDAC, which, in turn, may be expected to improve the quality of life and survival for those suffering from this devastating disease.
dc.description.sponsorship This manuscript and the original meeting that led to its development were supported by an educational grant from Astellas Pharma EMEA. Highfield Communication Consultancy, Oxford, UK (funded by Astellas Pharma EMEA) provided editorial assistance in the preparation of the manuscript.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Pancreatology. 2015;15(1):8-18
dc.rights © Elsevier. This is the published version of an article http://dx.doi.org/10.1016/j.pan.2014.10.001 that appeared in the journal Pancreatology. It is published in an Open Archive under an Elsevier user license. Details of this licence are available here: http://www.elsevier.com/about/open-access/open-access-policies/oa-license-policy/elsevier-user-license
dc.subject.other Pàncrees -- Tumors
dc.subject.other Tractament pal·liatiu
dc.title Addressing the challenges of pancreatic cancer: future directions for improving outcomes
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.pan.2014.10.001
dc.subject.keyword Management
dc.subject.keyword Outcomes
dc.subject.keyword PDAC
dc.subject.keyword Pancreas
dc.subject.keyword Pathogenesis
dc.subject.keyword Treatment
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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