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A drug pharmacodynamics and pharmacokinetics based approach towards stabilization of HIV infection dynamics

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dc.contributor.author Tretyakova, Rufina M.
dc.contributor.author Meyerhans, Andreas
dc.contributor.author Bocharov, Gennady A.
dc.date.accessioned 2016-02-23T14:09:52Z
dc.date.available 2016-11-03T03:00:04Z
dc.date.issued 2015
dc.identifier.citation Tretyakova RM, Meyerhans A, Bocharov GA. A drug pharmacodynamics and pharmacokinetics based approach towards stabilization of HIV infection dynamics. Russian Journal of Numerical Analysis and Mathematical Modelling. 2015; 30(3): 299-310. DOI 10.1515/rnam-2015-0027
dc.identifier.issn 0927-6467
dc.identifier.uri http://hdl.handle.net/10230/25930
dc.description.abstract In our study we developed a computational algorithm for finding optimal dosages of antiretroviral drug administration for the stabilization of HIV load at low levels. The novelty is that the pharmacokinetics and pharmacodynamics of the antiretroviral drugs were taken into account. A standard closed-loop control of HIV dynamics was constructed that stabilizes the viral load and the optimal drug administration mode was formulated. We analyze the appropriateness of the ‘drug efficacy’ based control and its relationship to a realistic drug dosage and kinetic models in the human body. The translation of the efficacy function into drug concentration is implemented via the pharmacodynamics model of the drug effect. Optimal approximation of the idealized concentration functions is based on the orthogonal projection on linear subspace of drug pharmacokinetics functions.
dc.description.sponsorship The research was funded by the Russian Science Foundation (Grant No. 15-11-00029)
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher De Gruyter
dc.relation.ispartof Russian Journal of Numerical Analysis and Mathematical Modelling. 2015; 30(3): 299-310
dc.rights © De Gruyter Published version available at http://www.degruyter.com/view/j/rnam.2015.30.issue-5/rnam-2015-0027/rnam-2015-0027.xml http://dx.doi.org/10.1515/rnam-2015-0027
dc.subject.other VIH (Virus)
dc.subject.other Farmacodinàmica
dc.title A drug pharmacodynamics and pharmacokinetics based approach towards stabilization of HIV infection dynamics
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1515/rnam-2015-0027
dc.subject.keyword HIV dynamics
dc.subject.keyword Stabilization
dc.subject.keyword Feedback control
dc.subject.keyword Pharmacodynamics
dc.subject.keyword Pharmacokinetics
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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