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Semantic Verbal Fluency Pattern, Dementia Rating Scores and Adaptive Behavior Correlate With Plasma Aβ42 Concentrations in Down Syndrome Young Adults.

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dc.contributor.author Del Hoyo Soriano, Laura
dc.contributor.author Xicota Vila, Laura, 1987-
dc.contributor.author Sánchez Benavides, Gonzalo
dc.contributor.author Cuenca Royo, Aida Ma, 1981-
dc.contributor.author Sola Llopis, Susana de
dc.contributor.author Langohr, Klaus
dc.contributor.author Fagundo, Ana B.
dc.contributor.author Farré Albaladejo, Magí
dc.contributor.author Dierssen, Mara
dc.contributor.author Torre Fornell, Rafael de la
dc.date.accessioned 2016-02-05T09:33:35Z
dc.date.available 2016-02-05T09:33:35Z
dc.date.issued 2015
dc.identifier.citation Hoyo LD, Xicota L, Sánchez-Benavides G, Cuenca-Royo A, de Sola S, Langohr K. et al. Semantic Verbal Fluency Pattern, Dementia Rating Scores and Adaptive Behavior Correlate With Plasma Aβ42 Concentrations in Down Syndrome Young Adults. Front Behav Neurosci. 2015 Nov 18;9:301. doi: 10.3389/fnbeh.2015.00301
dc.identifier.issn 1662-5153
dc.identifier.uri http://hdl.handle.net/10230/25740
dc.description.abstract Down syndrome (DS) is an intellectual disability (ID) disorder in which language and specifically, verbal fluency are strongly impaired domains; nearly all adults show neuropathology of Alzheimer's disease (AD), including amyloid deposition by their fifth decade of life. In the general population, verbal fluency deficits are considered a strong AD predictor being the semantic verbal fluency task (SVFT) a useful tool for enhancing early diagnostic. However, there is a lack of information about the association between the semantic verbal fluency pattern (SVFP) and the biological amyloidosis markers in DS. In the current study, we used the SVFT in young adults with DS to characterize their SVFP, assessing total generated words, clustering, and switching. We then explored its association with early indicators of dementia, adaptive behavior and amyloidosis biomarkers, using the Dementia Questionnaire for Persons with Intellectual Disability (DMR), the Adaptive Behavior Assessment System-Second Edition (ABAS-II), and plasma levels of Aβ peptides (Aβ40 and Aβ42), as a potent biomarker of AD. In DS, worse performance in SVFT and poorer communication skills were associated with higher plasma Aβ42 concentrations, a higher DMR score and impaired communication skills (ABAS-II). The total word production and switching ability in SVFT were good indicators of plasma Aβ42 concentration. In conclusion, we propose the SVFT as a good screening test for early detection of dementia and amyloidosis in young adults with DS.
dc.description.sponsorship This work was supported by grants, donations and agreements from Fondation Jérôme Lejeune (Paris, France), Instituto de Salud Carlos III FEDER, (PI11/00744), MINECO (SAF2010-19434 and SAF2013-49129-C2-1-R), EU (Era Net Neuron PCIN-2013-060), DIUE de la Generalitat de Catalunya (SGR 2009/1450 and SGR 2009/718).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Frontiers
dc.rights © 2015 Del Hoyo, Xicota, Sánchez-Benavides, Cuenca-Royo, de Sola, Langohr, Fagundo, Farre, Dierssen and de La Torre. This is an open-access article distributed under the terms of the http://creativecommons.org/licenses/by/4.0/). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.other Down, Síndrome de -- Aspectes genètics
dc.subject.other Demència
dc.title Semantic Verbal Fluency Pattern, Dementia Rating Scores and Adaptive Behavior Correlate With Plasma Aβ42 Concentrations in Down Syndrome Young Adults.
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3389/fnbeh.2015.00301
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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