Mostra el registre parcial de l'element
dc.contributor.author | Mascaraque, Ainhoa |
dc.contributor.author | Kowalczyk, Wioleta |
dc.contributor.author | Fernández, Tahia |
dc.contributor.author | Palomares, Francisca |
dc.contributor.author | Mayorga, Cristobalina |
dc.contributor.author | Andreu Martínez, David |
dc.contributor.author | Rojo, Javier |
dc.date.accessioned | 2016-02-01T15:27:51Z |
dc.date.available | 2016-02-01T15:27:51Z |
dc.date.issued | 2015 |
dc.identifier.citation | Mascaraque A, Kowalczyk W, Fernández T, Palomares F, Mayorga C, Andreu D et al. Glycodendropeptides stimulate dendritic cell maturation and T cell proliferation: a potential influenza A virus immunotherapy. MedChemComm. 2015;6:1755-60. DOI: 10.1039/C5MD00133A |
dc.identifier.issn | 2040-2503 |
dc.identifier.uri | http://hdl.handle.net/10230/25708 |
dc.description.abstract | Mannosylation facilitates uptake and internalization of immunogenic peptides by antigen-processing cells expressing mannose receptors at their surface, such as DC-SIGN, a lectin that plays a key role in the immune response against different pathogens. This internalization, processing and subsequent MHC presentation may result in a strong T cell stimulation. Here, we hypothesized that combining mannose glycodendrons with multivalent presentation of peptide epitopes in a likewise dendron format would yield hybrid constructs, named glycodendropeptides (GDPs), with the capacity to enhance peptide immunogenicity, hence providing a novel and versatile platform for applications in immunotherapy. Thus, GDPs of different valencies displaying the NP366–374 epitope, a conserved sequence from the influenza A virus nucleoprotein (NP), have been built by two click chemistry-based methodologies and assessed as potential flu vaccine candidates. Preliminary evaluation of the ability of these constructs to stimulate dendritic cell maturation and lymphocyte proliferation was promising, showing the highest-functionalized NP366–374 GDPs as inducing the strongest immunostimulatory effect. |
dc.description.sponsorship | This work was supported by the Instituto de Salud Carlos III (ISCIII) Thematic Networks and Co-operative Research Centres: RIRAAF (RD012/0013/0001 and RD012/0013/0016) and project ISCIII (PI12/02481); by Junta de Andalucía (CTS-7433) and the Nicolas Monardes Program (C-0044-2012 SAS 2013); and by Generalitat de Catalunya (SGR2009-00492) and Ministerio de Economía y Competitividad (MINECO), projects CTQ2011-23410 and SAF2011-24899. This work was co-financed by the European Regional Development Fund (ERDF) |
dc.format.mimetype | application/pdf |
dc.language.iso | eng |
dc.publisher | Royal Society of Chemistry |
dc.relation.ispartof | MedChemComm. 2015;6:1755-60 |
dc.rights | © This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/ |
dc.subject.other | Cèl·lules T |
dc.subject.other | Grip |
dc.title | Glycodendropeptides stimulate dendritic cell maturation and T cell proliferation: a potential influenza A virus immunotherapy |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | http://dx.doi.org/10.1039/C5MD00133A |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/3PN/SAF2011-24899 |
dc.rights.accessRights | info:eu-repo/semantics/openAccess |
dc.type.version | info:eu-repo/semantics/publishedVersion |