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Genetic evidence for an origin of the Armenians from Bronze Age mixing of multiple populations

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dc.contributor.author Haber, Marc, 1980-
dc.contributor.author Mezzavilla, Massimo
dc.contributor.author Xue, Yali
dc.contributor.author Comas, David, 1969-
dc.contributor.author Gasparini, Paolo
dc.contributor.author Zalloua, Pierre A.
dc.contributor.author Tyler-Smith, Chris
dc.date.accessioned 2016-01-25T18:31:32Z
dc.date.available 2016-01-25T18:31:32Z
dc.date.issued 2015
dc.identifier.citation Haber M, Mezzavilla M, Xue Y, Comas D, Gasparini P, Zalloua P et al. Genetic evidence for an origin of the Armenians from Bronze Age mixing of multiple populations. European journal of human genetics: EJHG. 2015;24:931-6. DOI: 10.1038/ejhg.2015.206
dc.identifier.issn 1018-4813
dc.identifier.uri http://hdl.handle.net/10230/25648
dc.description.abstract The Armenians are a culturally isolated population who historically inhabited a region in the Near East bounded by the Mediterranean and Black seas and the Caucasus, but remain under-represented in genetic studies and have a complex history including a major geographic displacement during World War I. Here, we analyse genome-wide variation in 173 Armenians and compare them with 78 other worldwide populations. We find that Armenians form a distinctive cluster linking the Near East, Europe, and the Caucasus. We show that Armenian diversity can be explained by several mixtures of Eurasian populations that occurred between 3000 and 2000 bce, a period characterized by major population migrations after the domestication of the horse, appearance of chariots, and the rise of advanced civilizations in the Near East. However, genetic signals of population mixture cease after 1200 bce when Bronze Age civilizations in the Eastern Mediterranean world suddenly and violently collapsed. Armenians have since remained isolated and genetic structure within the population developed 500 years ago when Armenia was divided between the Ottomans and the Safavid Empire in Iran. Finally, we show that Armenians have higher genetic affinity to Neolithic Europeans than other present-day Near Easterners, and that 29% of Armenian ancestry may originate from an ancestral population that is best represented by Neolithic Europeans
dc.description.sponsorship This work was supported by Wellcome Trust grant 098051
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Nature Publishing Group
dc.relation.ispartof European journal of human genetics: EJHG. 2015;24:931-6
dc.rights © Nature Publishing Group. http://dx.doi.org/10.1038/ejhg.2015.206. This work is licensed under a Creative Commons Attribution 4.0 International License
dc.rights.uri http://creativecommons.org/licenses/by/4.0
dc.subject.other Armènia
dc.subject.other Genètica de poblacions humanes
dc.title Genetic evidence for an origin of the Armenians from Bronze Age mixing of multiple populations
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1038/ejhg.2015.206
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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