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Spatiotemporal control of forkhead binding to DNA regulates the meiotic gene expression program

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dc.contributor.author Alves-Rodrigues, Isabel
dc.contributor.author Ferreira, Pedro G.
dc.contributor.author Moldón Vara, Alberto
dc.contributor.author Vivancos Prellezo, Ana
dc.contributor.author Hidalgo Hernando, Elena
dc.contributor.author Guigó Serra, Roderic
dc.contributor.author Ayté del Olmo, José
dc.date.accessioned 2016-01-22T18:35:22Z
dc.date.available 2016-01-22T18:35:22Z
dc.date.issued 2016
dc.identifier.citation Alves-Rodrigues I, Ferreira PG, Moldón A, Vivancos AP, Hidalgo E, Guigó R et al. Spatiotemporal control of forkhead binding to DNA regulates the meiotic gene expression program. Cell Reports. 2016;14(4):885-95. DOI: 10.1016/j.celrep.2015.12.074
dc.identifier.issn 2211-1247
dc.identifier.uri http://hdl.handle.net/10230/25642
dc.description.abstract Meiosis is a differentiated program of the cell cycle that is characterized by high levels of recombination followed by two nuclear divisions. In fission yeast, the genetic program during meiosis is regulated at multiple levels, including transcription, mRNA stabilization, and splicing. Mei4 is a forkhead transcription factor that controls the expression of mid-meiotic genes. Here, we describe that Fkh2, another forkhead transcription factor that is essential for mitotic cell-cycle progression, also plays a pivotal role in the control of meiosis. Fkh2 binding preexists in most Mei4-dependent genes, inhibiting their expression. During meiosis, Fkh2 is phosphorylated in a CDK/Cig2-dependent manner, decreasing its affinity for DNA, which creates a window of opportunity for Mei4 binding to its target genes. We propose that Fkh2 serves as a placeholder until the later appearance of Mei4 with a higher affinity for DNA that induces the expression of a subset of meiotic genes.
dc.description.sponsorship This work was supported by grants from the Spanish Ministerio de Economia y Competitividad (MINECO) (grants BFU2012-31939 and BFU2015-66347), PLAN E, and Feder. E.H. is a recipient of an ICREA Academia Award (Generalitat de Catalunya).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Cell Reports. 2016;14(4):885-95
dc.rights © 2016 The Authors. Published by Elsevier Ltd. Open access under CC BY-NC-ND license
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.other ADN
dc.subject.other Expressió gènica
dc.title Spatiotemporal control of forkhead binding to DNA regulates the meiotic gene expression program
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.celrep.2015.12.074
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2012-31939
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2015-66347
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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