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Tricyclic antidepressants block cholinergic nicotinic receptors and ATP secretion in bovine chromaffin cells

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dc.contributor.author Izaguirre, Victor
dc.contributor.author Fernández-Fernández, José Manuel, 1967-
dc.contributor.author Ceña, Valentin
dc.contributor.author González García, Carmen
dc.date.accessioned 2016-01-21T18:29:47Z
dc.date.available 2016-01-21T18:29:47Z
dc.date.issued 1997
dc.identifier.citation Izaguirre V, Fernández-Fernández JM, Ceña V, González-García C. Tricyclic antidepressants block cholinergic nicotinic receptors and ATP secretion in bovine chromaffin cells. FEBS letters. 1997;418(1-2):39-42. DOI: 10.1016/S0014-5793(97)01343-4
dc.identifier.issn 0014-5793
dc.identifier.uri http://hdl.handle.net/10230/25631
dc.description.abstract Nicotine-induced ATP secretion from chromaffin cells was blocked by imipramine and desipramine. This blocking action took place on both, fast and slow, components of ATP secretion. Exposure of chromaffin cells to nicotine (10 microM) for 4 s induced an inward current of about -155 pA. Imipramine and desipramine blocked, in a concentration-dependent manner, both peak inward current and total charge influx in response to nicotine. In addition, imipramine and desipramine partially (40%) blocked depolarization-induced ATP secretion and Ca2+ currents evoked by high K+. This suggests that tricyclic antidepressants block nicotine-induced ATP secretion by acting on two targets: one is the nicotinic receptor itself and the second one are voltage-dependent Ca2+ channels.
dc.description.sponsorship This work has been supported in part by grants from Fondo de Investigaciones Sanitarias (95/1655) to C.G.G.; from DGICYT (PM92-0112), Comision Interministerial de Ciencia y Tecnologia, Plan Nacional de Salud (SAF96-0169) and Fundacion Navarro-Tripodi to V.C.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof FEBS letters. 1997;418(1-2):39-42
dc.rights © Elsevier This is the published version of an article http://dx.doi.org/10.1016/S0014-5793(97)01343-4 that appeared in the journal Developmental cell. It is published in an Open Archive under an Elsevier user license. Details of this licence are available here: http://www.elsevier.com/about/open-access/open-access-policies/oa-license-policy/elsevier-user-license
dc.subject.other Nicotina
dc.title Tricyclic antidepressants block cholinergic nicotinic receptors and ATP secretion in bovine chromaffin cells
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/S0014-5793(97)01343-4
dc.subject.keyword Nicotine
dc.subject.keyword ATP secretion
dc.subject.keyword Chromaffin cell
dc.subject.keyword Imipramine
dc.subject.keyword Desipramine
dc.subject.keyword Calcium channel
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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