Mostra el registre parcial de l'element
dc.contributor.author | Tilgner, Hagen, 1980- |
dc.contributor.author | Guigó Serra, Roderic |
dc.date.accessioned | 2016-01-12T13:32:06Z |
dc.date.available | 2016-01-12T13:32:06Z |
dc.date.issued | 2010 |
dc.identifier.citation | Tilgner H, Guigó R. From chromatin to splicing: RNA-processing as a total artwork. Epigenetics. 2010; 5(3): 180-184. DOI 10.4161/epi.5.3.11319 |
dc.identifier.issn | 1559-2294 |
dc.identifier.uri | http://hdl.handle.net/10230/25556 |
dc.description.abstract | RNA plays a central role in the determination of the phenotype of the cell. The molecular mechanisms involved in primary RNA synthesis and subsequent post-processing are not completely understood, but there is increasing evidence that they are more tightly coupled than previously expected. The analyses by a number of groups of recently published genome wide maps of chromatin structure have further uncovered a role for primary chromatin structure in RNA processing. Indeed, these analyses have revealed that nucleosomes show a characteristic occupancy pattern in exonic regions of metazoan genomes. The pattern is strongly indicative of an implication of nucleosome positioning in exon recognition during pre-mRNA splicing. Characteristic exonic patterns have also been observed for a number of histone modifications, suggesting the possibility that chromatin state plays a direct role in the regulation of splicing |
dc.format.mimetype | application/pdf |
dc.language.iso | eng |
dc.publisher | Taylor & Francis (Routledge) |
dc.relation.ispartof | Epigenetics. 2010; 5(3): 180-184 |
dc.rights | © 2010 Landes Bioscience. This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/3.0/ |
dc.subject.other | Cromatina |
dc.subject.other | RNA missatger |
dc.subject.other | Exons |
dc.title | From chromatin to splicing: RNA-processing as a total artwork |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | http://dx.doi.org/10.4161/epi.5.3.11319 |
dc.subject.keyword | Splicing |
dc.subject.keyword | Transcription |
dc.subject.keyword | Chromatin |
dc.subject.keyword | Epigenetics |
dc.subject.keyword | Nucleosome positioning |
dc.subject.keyword | Bioinformatics |
dc.rights.accessRights | info:eu-repo/semantics/openAccess |
dc.type.version | info:eu-repo/semantics/publishedVersion |