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Comparison of quality of life after stereotactic body radiotherapy and surgery for early-stage prostate cancer

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dc.contributor.author Katz, Alan
dc.contributor.author Ferrer Forés, Maria Montserrat
dc.contributor.author Alonso Caballero, Jordi
dc.contributor.author Becerra Bachino, Virginia, 1975-
dc.contributor.author Cunillera, Oriol
dc.contributor.author Garin Boronat, Olatz, 1979-
dc.contributor.author Pardo Cladellas, Yolanda
dc.contributor.author Pont Acuña, Àngels
dc.contributor.author Multicentric Spanish Group of Clinically Localized Prostate Cancer
dc.date.accessioned 2015-12-14T14:49:40Z
dc.date.available 2015-12-14T14:49:40Z
dc.date.issued 2012
dc.identifier.citation Katz A, Ferrer M, Suárez JF; Multicentric Spanish Group of Clinically Localized Prostate Cancer. Comparison of quality of life after stereotactic body radiotherapy and surgery for early-stage prostate cancer. Radiation oncology. 2012. 7: 194. DOI 10.1186/1748-717X-7-194
dc.identifier.issn 1748-717X
dc.identifier.uri http://hdl.handle.net/10230/25421
dc.description.abstract BACKGROUND: As the long-term efficacy of stereotactic body radiation therapy (SBRT) becomes established and other prostate cancer treatment approaches are refined and improved, examination of quality of life (QOL) following prostate cancer treatment is critical in driving both patient and clinical treatment decisions. We present the first study to compare QOL after SBRT and radical prostatectomy, with QOL assessed at approximately the same times pre- and post-treatment and using the same validated QOL instrument. METHODS: Patients with clinically localized prostate cancer were treated with either radical prostatectomy (n = 123 Spanish patients) or SBRT (n = 216 American patients). QOL was assessed using the Expanded Prostate Cancer Index Composite (EPIC) grouped into urinary, sexual, and bowel domains. For comparison purposes, SBRT EPIC data at baseline, 3 weeks, 5, 11, 24, and 36 months were compared to surgery data at baseline, 1, 6, 12, 24, and 36 months. Differences in patient characteristics between the two groups were assessed using Chi-squared tests for categorical variables and t-tests for continuous variables. Generalized estimating equation (GEE) models were constructed for each EPIC scale to account for correlation among repeated measures and used to assess the effect of treatment on QOL. RESULTS: The largest differences in QOL occurred in the first 1-6 months after treatment, with larger declines following surgery in urinary and sexual QOL as compared to SBRT, and a larger decline in bowel QOL following SBRT as compared to surgery. Long-term urinary and sexual QOL declines remained clinically significantly lower for surgery patients but not for SBRT patients. CONCLUSIONS: Overall, these results may have implications for patient and physician clinical decision making which are often influenced by QOL. These differences in sexual, urinary and bowel QOL should be closely considered in selecting the right treatment, especially in evaluating the value of non-invasive treatments, such as SBRT.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartof Radiation oncology. 2012. 7: 194
dc.rights © Katz et al. Creative Commons Attribution License http://creativecommons.org/licenses/by/2.0/
dc.rights.uri http://creativecommons.org/licenses/by/2.0/
dc.subject.other Pròstata -- Càncer -- Tractament
dc.subject.other Impotència sexual
dc.title Comparison of quality of life after stereotactic body radiotherapy and surgery for early-stage prostate cancer
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1186/1748-717X-7-194
dc.subject.keyword Prostate cancer
dc.subject.keyword Prostatectomy
dc.subject.keyword Quality of life
dc.subject.keyword Stereotactic body radiotherapy
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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