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PAI-1-regulated miR-21 defines a novel age-associated fibrogenic pathway in muscular dystrophy

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dc.contributor.author Ardite, Esther
dc.contributor.author Perdiguero, Eusebio, 1968-
dc.contributor.author Vidal Iglesias, Berta
dc.contributor.author Gutarra, Susana
dc.contributor.author Serrano, Antonio L.
dc.contributor.author Muñoz Cánoves, Pura, 1962-
dc.date.accessioned 2015-12-10T15:50:19Z
dc.date.available 2015-12-10T15:50:19Z
dc.date.issued 2012
dc.identifier.citation Ardite E, Perdiguero E, Vidal B, Gutarra S, Serrano AL, Muñoz-Cánoves P et al. PAI-1-regulated miR-21 defines a novel age-associated fibrogenic pathway in muscular dystrophy. Journal of cell biology. 2012. 196(1): 163-175. DOI 10.1083/jcb.201105013
dc.identifier.issn 0021-9525
dc.identifier.uri http://hdl.handle.net/10230/25372
dc.description.abstract There is a widespread awareness that the wealth of preclinical toxicity data that the pharmaceutical industry has generated in recent decades is not exploited as efficiently as it could be. Enhanced data availability for compound comparison ("read-across"), or for data mining to build predictive tools, should lead to a more efficient drug development process and contribute to the reduction of animal use (3Rs principle). In order to achieve these goals, a consortium approach, grouping numbers of relevant partners, is required. The eTOX ("electronic toxicity") consortium represents such a project and is a public-private partnership within the framework of the European Innovative Medicines Initiative (IMI). The project aims at the development of in silico prediction systems for organ and in vivo toxicity. The backbone of the project will be a database consisting of preclinical toxicity data for drug compounds or candidates extracted from previously unpublished, legacy reports from thirteen European and European operation-based pharmaceutical companies. The database will be enhanced by incorporation of publically available, high quality toxicology data. Seven academic institutes and five small-to-medium size enterprises (SMEs) contribute with their expertise in data gathering, database curation, data mining, chemoinformatics and predictive systems development. The outcome of the project will be a predictive system contributing to early potential hazard identification and risk assessment during the drug development process. The concept and strategy of the eTOX project is described here, together with current achievements and future deliverables.
dc.description.sponsorship The authors acknowledge funding from the Ministerio de Ciencia e Innovación (PLE2009-0124, SAF2009-09782, FIS-PS09/01267, and Centro de Investigación Biomédica en Red, Enfermedades Neurodegenerativas), AFM, Fundació La Marató de TV3, Muscular Dystrophy Association, and MYOAGE, OptiStem, and EndoStem (EU-FP7).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Rockefeller University Press
dc.relation.ispartof Journal of cell biology. 2012. 196(1): 163-175
dc.rights © Ardite et al., 2012. This article is distributed under a Creative Commons License Attribution–Noncommercial–Share Alike 3.0 Unported license.
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0
dc.subject.other Distròfia muscular
dc.title PAI-1-regulated miR-21 defines a novel age-associated fibrogenic pathway in muscular dystrophy
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/ijms13033820
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/223576
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/223098
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/PLE2009-0124
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2009-09782
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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