Aortic aneurysms are a class of frequent cardiovascular disease related to an increased risk of life-threating complications, such as aortic dissection and rupture. These acute events are characterized by a very bad ...
Alzheimer’s disease (AD) is a complex neurodegenerative disease that leads to progressive cognitive decline and memory loss. Nowadays, it is still very challenging to diagnose AD due to its complexity, the inter-individual ...
Some bacteria have shown the ability to naturally survive to extreme environments, even Outer Space. These bacteria have natural genetic mechanisms to protect and repair the DNA damage these severe conditions can cause, ...
The human microbiome plays an essential role in maintaining the host health. One of the most common bacteria present in the skin microbiota is Cutibacterium acnes (C.acnes) which is known for being involved in the homeostasis ...
Multiple sclerosis is an autoimmune condition in which the immune system mistakenly attacks the myelin sheath, causing that messages travelling along the nerves become slowed or disrupted. Currently, the severity of the ...
Down syndrome (DS) is the most common cause of intellectual disability and a genetic cause of early Alzheimer’s disease, produced by trisomy of whole or part of chromosome 21. Nevertheless, no gold-standard clinical treatment ...
Osteoarthritis (OA) is a common condition characterised by the degradation of the articular cartilage that leads to stiff and painful joints. OA is related with the dysregulation of the cartilage chondrocyte’s activity, ...
The hip joint is one of the body’s largest weight-bearing joints and is commonly affected by osteoarthritis (OA). With hip osteoarthritis the cartilage within the joint begins to break down and the underlying bone begins ...
The mechanisms of biological evolution also apply to artificial phenomena such as culture and technology, and the evolution of video games through history has been shaped by the evolution of technology itself. In particular, ...
Tumor cells heterogeneity is one of the most important handicaps in fighting cancer. Such heterogeneity is mainly driven by genomic instability, epigenetics and different sources of stochasticity. Heterogeneity provides ...
The pro-cognitive effects of Vagus Nerve Stimulation (VNS) observed in some small offlabel studies have raised enthusiasm for its use to ameliorate cognitive performance. Relatedly, auricular transcutaneous VNS (atVNS) has ...
Synthetic biology is a field of Biology that involves redesigning organisms for useful purposes by rationally engineering them to have new abilities. The potential to reengineer living organisms has provided tools to address ...
Whole genome doubling (WGD) is one of the most common events in the early stages of cancer evolution. However, a consistent explanation for the pervasiveness of WGD across cancer types remains elusive. The duplication of ...
It is known that, after the application of sufficiently high external electric fields, defects are formed in the cell membrane at the molecular level, non-selectively increasing its permeability, and therefore increasing ...
Articular cartilage degeneration is consequence of knee osteoarthritis (OA). There is not a clear aetiology or understanding of OA’s natural course since it is a multifactorial condition. Finite Element models can be used ...
Cobalamin de novo synthesis appears to be restricted solely to some bacteria and archaea. In humans, this nutrient is usually acquired through the consumption of animal products. However, it can lead to a vitamin B12 ...
Percutaneous left atrial appendage (LAA) occlusion interventions are an alternative to oral anticoagulants for cardioembolic stroke prevention in atrial fibrillation patients. Preoperative insights into how the occluder ...
Ever since the first measurements of the human electroencephalogram, it is known that neural activity in the alpha frequency (~10Hz) is dominant during relaxed wakefulness. The frequency peak of alpha varies between ...
Sleep is a complex physiological process responsible for several developmental, restorative and cognitive processes. Sleep related disorders diminish life quality, and their diagnosis relies on classifying 8-hour ...
Advances in medical imaging and computational power have led to the emergence of patient-specific computational modelling for non-invasive coronary stenosis severity assessment. Computational fluid dynamics (CFD) models ...