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Scientific competency questions as the basis for semantically enriched open pharmacological space development

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dc.contributor.author Azzaoui, Kamal
dc.contributor.author Jacoby, Edgar
dc.contributor.author Senger, Stefan
dc.contributor.author Cuadrado Rodríguez, Emiliano
dc.contributor.author Loza, Mabel
dc.contributor.author Zdrazil, Barbara
dc.contributor.author Pinto, Marta
dc.contributor.author Williams, Antony J.
dc.contributor.author Torre, Victor de la
dc.contributor.author Mestres i López, Jordi
dc.contributor.author Pastor Maeso, Manuel
dc.contributor.author Taboureau, Olivier
dc.contributor.author Rarey, Matthias
dc.contributor.author Chichester, Christine
dc.contributor.author Pettifer, Steve
dc.contributor.author Blomberg, Niklas
dc.contributor.author Harland, Lee
dc.contributor.author Williams-Jones, Bryn
dc.contributor.author Ecker, Gerhard F.
dc.date.accessioned 2015-11-25T15:43:47Z
dc.date.available 2015-11-25T15:43:47Z
dc.date.issued 2013
dc.identifier.citation Azzaoui K, Jacoby E, Senger S, Rodríguez EC, Loza M, Zdrazil B, et al. Scientific competency questions as the basis for semantically enriched open pharmacological space development. Drug discovery today. 2013; 18(17-18): 843-852. DOI 10.1016/j.drudis.2013.05.008
dc.identifier.issn 1359-6446
dc.identifier.uri http://hdl.handle.net/10230/25218
dc.description.abstract Molecular information systems play an important part in modern data-driven drug discovery. They do not only support decision making but also enable new discoveries via association and inference. In this review, we outline the scientific requirements identified by the Innovative Medicines Initiative (IMI) Open PHACTS consortium for the design of an open pharmacological space (OPS) information system. The focus of this work is the integration of compound-target-pathway-disease/phenotype data for public and industrial drug discovery research. Typical scientific competency questions provided by the consortium members will be analyzed based on the underlying data concepts and associations needed to answer the questions. Publicly available data sources used to target these questions as well as the need for and potential of semantic web-based technology will be presented.
dc.description.sponsorship The research leading to these results has received support from the Innovative Medicines Initiative Joint Undertaking under grant agreement no. [115191], resources of which are composed of financial contribution from the European Union’s Seventh Framework Programme (FP7/2007-2013) and inkind contribution of EFPIA companies.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Drug discovery today. 2013; 18(17-18): 843-852
dc.rights © 2013 Elsevier Ltd. All rights reserved.
dc.subject.other Medicaments -- Desenvolupament
dc.subject.other Farmàcia -- Investigació
dc.subject.other Mineria de dades
dc.title Scientific competency questions as the basis for semantically enriched open pharmacological space development
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.drudis.2013.05.008
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP6/115191
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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