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Cancer-associated fibroblast and M2 macrophage markers together predict outcome in colorectal cancer patients

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dc.contributor.author Herrera, Mercedes
dc.contributor.author Herrera, Alberto
dc.contributor.author Domínguez, Gemma
dc.contributor.author Silva, Javier
dc.contributor.author García, Vanesa
dc.contributor.author García, Jose M.
dc.contributor.author Gómez, Irene
dc.contributor.author Soldevilla, Beatriz
dc.contributor.author Muñoz, Concepción
dc.contributor.author Provencio, Mariano
dc.contributor.author Campos Martin, Yolanda
dc.contributor.author García de Herreros, Antonio
dc.contributor.author Casal, José Ignacio
dc.contributor.author Bonilla, Félix
dc.contributor.author Peña, Cristina
dc.date.accessioned 2015-11-25T13:41:59Z
dc.date.available 2015-11-25T13:41:59Z
dc.date.issued 2013
dc.identifier.citation Herrera M, Herrera A, Domínguez G, Silva J, García V, García JM et al. Cancer-associated fibroblast and M2 macrophage markers together predict outcome in colorectal cancer patients. Cancer science. 2013; 104(4): 437-444. DOI 10.1111/cas.12096
dc.identifier.issn 1347-9032
dc.identifier.uri http://hdl.handle.net/10230/25212
dc.description.abstract Tumor epithelial cells within a tumor coexist with a complex microenvironment in which a variety of interactions between its various components determine the behavior of the primary tumors. Cancer-associated fibroblasts (CAF) and M2 macrophages, characterized by high expression of different markers, including α-SMA, FSP1 and FAP, or CD163 and DCSIGN, respectively, are involved in the malignancy of different tumors. In the present study, expression of the above markers in CAF and M2 macrophages was analyzed using RT-PCR and immunohistochemistry in the normal mucosa and tumor tissue from a cohort of 289 colorectal cancer patients. Expression of CAF and M2 markers is associated with the clinical outcome of colorectal cancer patients. Moreover, the combination of CAF and M2 markers identifies three groups of patients with clear differences in the progression of the disease. This combined variable could be a decisive factor in the survival of advanced-stage patients. Taken together, these analyses demonstrate the prognostic involvement of interrelationships between DCSIGN, CD163, α-SMA, FSP1 and FAP markers in the survival of colon cancer patients.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Japanese Cancer Association
dc.relation.ispartof Cancer science. 2013; 104(4): 437-444
dc.rights © 2013 Japanese Cancer Association
dc.subject.other Tumors
dc.subject.other Prognosi
dc.title Cancer-associated fibroblast and M2 macrophage markers together predict outcome in colorectal cancer patients
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1111/cas.12096
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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