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dc.contributor.author Jiménez, Alba
dc.contributor.author Cotterell, James
dc.contributor.author Munteanu, Andreea
dc.contributor.author Sharpe, James
dc.date.accessioned 2015-11-19T14:53:42Z
dc.date.available 2015-11-19T14:53:42Z
dc.date.issued 2015
dc.identifier.citation Jiménez A, Cotterell J, Munteanu A, Sharpe J. Dynamics of gene circuits shapes evolvability. Proceedings of the National Academy of Sciences of the United States of America. 2015;112(7): 2103-8. DOI: 10.1073/pnas.1411065112
dc.identifier.issn 0027-8424
dc.identifier.uri http://hdl.handle.net/10230/25159
dc.description.abstract To what extent does the dynamical mechanism producing a specific biological phenotype bias the ability to evolve into novel phenotypes? We use the interpretation of a morphogen gradient into a single stripe of gene expression as a model phenotype. Although there are thousands of three-gene circuit topologies that can robustly develop a stripe of gene expression, the vast majority of these circuits use one of just six fundamentally different dynamical mechanisms. Here we explore the potential for gene circuits that use each of these six mechanisms to evolve novel phenotypes such as multiple stripes, inverted stripes, and gradients of gene expression. Through a comprehensive and systematic analysis, we find that circuits that use alternative mechanisms differ in the likelihood of reaching novel phenotypes through mutation. We characterize the phenotypic transitions and identify key ingredients of the evolutionary potential, such as sensitive interactions and phenotypic hubs. Finally, we provide an intuitive understanding on how the modular design of a particular mechanism favors the access to novel phenotypes. Our work illustrates how the dynamical mechanism by which an organism develops constrains how it can evolve. It is striking that these dynamical mechanisms and their impact on evolvability can be observed even for such an apparently simple patterning task, performed by just three-node circuits.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Cold Spring Harbor Laboratory Press
dc.relation.ispartof Proceedings of the National Academy of Sciences of the United States of America. 2015;112(7):2103-8
dc.rights Freely available online through the PNAS open access option
dc.subject.other Evolució molecular
dc.subject.other Regulació genètica
dc.subject.other Biologia computacional
dc.subject.other RNA missatger
dc.title Dynamics of gene circuits shapes evolvability
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1073/pnas.1411065112
dc.subject.keyword Dynamical mechanism
dc.subject.keyword Phenotypic innovation
dc.subject.keyword Genotype–phenotype maps
dc.subject.keyword Developmental constraints
dc.subject.keyword Evolvability
dc.subject.keyword Evolució molecular
dc.subject.keyword Regulació genètica
dc.subject.keyword Biologia computacional
dc.subject.keyword RNA missatger
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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