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TCS: a web server for multiple sequence alignment evaluation and phylogenetic reconstruction

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dc.contributor.author Chang, Jia-Ming, 1978-
dc.contributor.author Di Tommaso, Paolo
dc.contributor.author Lefort, Vincent
dc.contributor.author Gascuel, Olivier
dc.contributor.author Notredame, Cedric
dc.date.accessioned 2015-11-18T13:09:21Z
dc.date.available 2015-11-18T13:09:21Z
dc.date.issued 2015
dc.identifier.citation Chang JM, Di Tommaso P, Lefort V, Gascuel O, Notredame C. TCS: a web server for multiple sequence alignment evaluation and phylogenetic reconstruction. Nucleic acids research. 2015; 43(W1): W3-W6. DOI 10.1093/nar/gkv310
dc.identifier.issn 0305-1048
dc.identifier.uri http://hdl.handle.net/10230/25135
dc.description.abstract This article introduces the Transitive Consistency Score (TCS) web server; a service making it possible to estimate the local reliability of protein multiple sequence alignments (MSAs) using the TCS index. The evaluation can be used to identify the aligned positions most likely to contain structurally analogous residues and also most likely to support an accurate phylogenetic reconstruction. The TCS scoring scheme has been shown to be accurate predictor of structural alignment correctness among commonly used methods. It has also been shown to outperform common filtering schemes like Gblocks or trimAl when doing MSA post-processing prior to phylogenetic tree reconstruction. The web server is available from http://tcoffee.crg.cat/tcs.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartof Nucleic acids research. 2015; 43(W1): W3-W6
dc.rights © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.other Servidors web
dc.subject.other Filogènia
dc.title TCS: a web server for multiple sequence alignment evaluation and phylogenetic reconstruction
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1093/nar/gkv310
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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