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Genome, transcriptome, and functional analyses of penicillium expansum provide new insights into secondary metabolism and pathogenicity

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dc.contributor.author Ballester, Ana Rosa
dc.contributor.author Marcet Houben, Marina
dc.contributor.author Levin, Elena
dc.contributor.author Sela, Noa
dc.contributor.author Selma Lázaro, Cristina
dc.contributor.author Carmona, Lourdes
dc.contributor.author Wisniewski, Michael
dc.contributor.author Droby, Samir
dc.contributor.author González Candelas, Luis
dc.contributor.author Gabaldón Estevan, Juan Antonio, 1973-
dc.date.accessioned 2015-11-16T14:03:40Z
dc.date.available 2015-11-16T14:03:40Z
dc.date.issued 2015
dc.identifier.citation Ballester AR, Marcet-Houben M, Levin E, Sela N, Selma-Lázaro C, Carmona L et al. Genome, transcriptome, and functional analyses of penicillium expansum provide new insights into secondary metabolism and pathogenicity. Molecular plant-microbe interactions: MPMI. 2015;28(3):232-48. DOI: 10.1094/MPMI-09-14-0261-FI
dc.identifier.issn 0894-0282
dc.identifier.uri http://hdl.handle.net/10230/25102
dc.description.abstract The relationship between secondary metabolism and infection in pathogenic fungi has remained largely elusive. The genus Penicillium comprises a group of plant pathogens with varying host specificities and with the ability to produce a wide array of secondary metabolites. The genomes of three Penicillium expansum strains, the main postharvest pathogen of pome fruit, and one Pencillium italicum strain, a postharvest pathogen of citrus fruit, were sequenced and compared with 24 other fungal species. A genomic analysis of gene clusters responsible for the production of secondary metabolites was performed. Putative virulence factors in P. expansum were identified by means of a transcriptomic analysis of apple fruits during the course of infection. Despite a major genome contraction, P. expansum is the Penicillium species with the largest potential for the production of secondary metabolites. Results using knockout mutants clearly demonstrated that neither patulin nor citrinin are required by P. expansum to successfully infect apples. Li et al. ( MPMI-12-14-0398-FI ) reported similar results and conclusions in their recently accepted paper.
dc.description.sponsorship Work at L. González-Candelas’ lab was partially supported by the Spanish Ministry of Economy and Innovation (Research Grants AGL-2008-04828-C03-02 and AGL2011-30519-C03-01) and by the Generalitat Valenciana, Spain(PROMETEO/2010/010 and PROMETEOII/2014/027). A.-R. Ballester is grateful to CSIC and the European Social Fund for her postdoctoral contract JAE-Doc. C. Selma-Lázaro is recipient of a FPI Predoctoral fellowship from the Spanish MICINN (BES-2012-054595). The T. Gabaldón group research is funded, in part, by a grant from the Spanish ministry of Economy and Competitiveness (BIO2012-37161), a Grant from the Qatar National Research Fund grant (NPRP 5-298-3-086), and a grant from the European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013)/ERC (Grant Agreement n. ERC-2012- StG-310325).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher APS Press
dc.relation.ispartof Molecular plant-microbe interactions: MPMI. 2015;28(3):232-48
dc.rights © The Author 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
dc.subject.other Fongs patògens
dc.subject.other Fongs -- Genètica
dc.title Genome, transcriptome, and functional analyses of penicillium expansum provide new insights into secondary metabolism and pathogenicity
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1094/MPMI-09-14-0261-FI
dc.relation.projectID info:eu-repo/grantAgreement/EC/ERC/310325
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2008-04828
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2011-30519
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BES2012-054595
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BIO2012-37161
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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