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Degeneration of the nonrecombining regions in the mating-type chromosomes of the anther-smut fungi

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dc.contributor.author Fontanillas, Eric
dc.contributor.author E. Hood, Michael
dc.contributor.author Badouin, Hélène
dc.contributor.author Petit, Elsa
dc.contributor.author Barbe, Valérie
dc.contributor.author Gouzy, Jérôme
dc.contributor.author Vienne, Damien M. de
dc.contributor.author Aguileta, Gabriela
dc.contributor.author Poulain, Julie
dc.contributor.author Wincker, Patrick
dc.contributor.author Chen, Zehua
dc.contributor.author Toh, Su San
dc.contributor.author Cuomo, Christina A.
dc.contributor.author Perlin, Michael H.
dc.contributor.author Gladieux, Pierre
dc.contributor.author Giraud, Tatiana
dc.date.accessioned 2015-11-16T13:08:50Z
dc.date.available 2015-11-16T13:08:50Z
dc.date.issued 2015
dc.identifier.citation Fontanillas E, Hood ME, Badouin H, Petit E, Barbe V, Gouzy J et al. Degeneration of the nonrecombining regions in the mating-type chromosomes of the anther-smut fungi. Molecular biology and evolution. 2015; 32(4): 928-943. DOI 10.1093/molbev/msu396
dc.identifier.issn 0737-4038
dc.identifier.uri http://hdl.handle.net/10230/25100
dc.description.abstract Dimorphic mating-type chromosomes in fungi are excellent models for understanding the genomic consequences of recombination suppression. Their suppressed recombination and reduced effective population size are expected to limit the efficacy of natural selection, leading to genomic degeneration. Our aim was to identify the sequences of the mating-type chromosomes (a1 and a2) of the anther-smut fungi and to investigate degeneration in their nonrecombining regions. We used the haploid a1 Microbotryum lychnidis-dioicae reference genome sequence. The a1 and a2 mating-type chromosomes were both isolated electrophoretically and sequenced. Integration with restriction-digest optical maps identified regions of recombination and nonrecombination in the mating-type chromosomes. Genome sequence data were also obtained for 12 other Microbotryum species. We found strong evidence of degeneration across the genus in the nonrecombining regions of the mating-type chromosomes, with significantly higher rates of nonsynonymous substitution (dN/dS) than in nonmating-type chromosomes or in recombining regions of the mating-type chromosomes. The nonrecombining regions of the mating-type chromosomes also showed high transposable element content, weak gene expression, and gene losses. The levels of degeneration did not differ between the a1 and a2 mating-type chromosomes, consistent with the lack of homogametic/heterogametic asymmetry between them, and contrasting with X/Y or Z/W sex chromosomes.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartof Molecular biology and evolution. 2015; 32(4): 928-943
dc.rights © The Author 2014. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
dc.subject.other Fongs -- Genètica
dc.title Degeneration of the nonrecombining regions in the mating-type chromosomes of the anther-smut fungi
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1093/molbev/msu396
dc.subject.keyword Y chromosome
dc.subject.keyword Silene latifolia
dc.subject.keyword Microbotryum violaceum
dc.subject.keyword PAR
dc.subject.keyword Evolutionary strata
dc.subject.keyword Autosomes
dc.subject.keyword Allosomes
dc.subject.keyword Genetic map
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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