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Dynamical feature extraction at the sensory periphery guides chemotaxis

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dc.contributor.author Schulze, Aljoscha, 1980-
dc.contributor.author Gómez Marín, Alex
dc.contributor.author Rajendran, Vani G.
dc.contributor.author Lott, Gus
dc.contributor.author Musy, Marco
dc.contributor.author Ahammad, Parvez
dc.contributor.author Deogade, Ajinkya, 1989-
dc.contributor.author Sharpe, James
dc.contributor.author Riedl, Julia, 1981-
dc.contributor.author Jarriault, David
dc.contributor.author Trautman, Eric T.
dc.contributor.author Werner, Christopher
dc.contributor.author Venkadesan, Madhusudhan
dc.contributor.author Druckmann, Shaul
dc.contributor.author Jayaraman, Vivek
dc.contributor.author Louis, Matthieu
dc.date.accessioned 2015-11-10T14:22:48Z
dc.date.available 2015-11-10T14:22:48Z
dc.date.issued 2015
dc.identifier.citation Schulze A, Gomez-Marin A, Rajendran VG, Lott G, Musy M, Ahammad P, Deogade A et al. Dynamical feature extraction at the sensory periphery guides chemotaxis. eLife. 2015;4:e06694. DOI: 10.7554/eLife.06694.001
dc.identifier.issn 2050-084X
dc.identifier.uri http://hdl.handle.net/10230/25034
dc.description.abstract Behavioral strategies employed for chemotaxis have been described across phyla, but the sensorimotor basis of this phenomenon has seldom been studied in naturalistic contexts. Here, we examine how signals experienced during free olfactory behaviors are processed by first-order olfactory sensory neurons (OSNs) of the Drosophila larva. We find that OSNs can act as differentiators that transiently normalize stimulus intensity—a property potentially derived from a combination of integral feedback and feed-forward regulation of olfactory transduction. In olfactory virtual reality experiments, we report that high activity levels of the OSN suppress turning, where as low activity levels facilitate turning. Using a generalized linear model, we explain how peripheral encoding of olfactory stimuli modulates the probability of switching from a run to a turn. Our work clarifies the link between computations carried out at the sensory periphery and action selection underlying navigation in odor gradients.
dc.description.sponsorship This work was supported by the EU project “Marie-Curie Action: Initial Training Networks” (EC FP7-PEOPLE-2011-ITN, grant number 289941).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher eLife
dc.relation.ispartof eLife. 2015;4:e06694
dc.rights Copyright Schulze et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.other Drosòfila -- Genètica
dc.subject.other Neurones sensorials
dc.title Dynamical feature extraction at the sensory periphery guides chemotaxis
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.7554/eLife.06694.001
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/289941
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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