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Quantitative system drift compensates for altered maternal inputs to the gap gene network of the scuttle fly Megaselia abdita

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dc.contributor.author Karl R., Wotton
dc.contributor.author Jiménez Guri, Eva
dc.contributor.author Crombach, Anton
dc.contributor.author Janssens, Hilde
dc.contributor.author Alcaine Colet, Anna
dc.contributor.author Lemke, Steffen
dc.contributor.author Schmidt Ott, Urs
dc.contributor.author Jaeger, Johannes, 1973-
dc.date.accessioned 2015-11-10T13:54:16Z
dc.date.available 2015-11-10T13:54:16Z
dc.date.issued 2015
dc.identifier.citation Wotton KR, Jiménez-Guri E, Crombach A, Janssens H, Alcaine-Colet A, Lemke S et al. Quantitative system drift compensates for altered maternal inputs to the gap gene network of the scuttle fly Megaselia abdita. Elife. 2015; 4: e04785. DOI 10.7554/eLife.04785.001
dc.identifier.issn 2050-084X
dc.identifier.uri http://hdl.handle.net/10230/25033
dc.description.abstract The segmentation gene network in insects can produce equivalent phenotypic outputs despite differences in upstream regulatory inputs between species. We investigate the mechanistic basis of this phenomenon through a systems-level analysis of the gap gene network in the scuttle fly Megaselia abdita (Phoridae). It combines quantification of gene expression at high spatio-temporal resolution with systematic knock-downs by RNA interference (RNAi). Initiation and dynamics of gap gene expression differ markedly between M. abdita and Drosophila melanogaster, while the output of the system converges to equivalent patterns at the end of the blastoderm stage. Although the qualitative structure of the gap gene network is conserved, there are differences in the strength of regulatory interactions between species. We term such network rewiring ‘quantitative system drift’. It provides a mechanistic explanation for the developmental hourglass model in the dipteran lineage. Quantitative system drift is likely to be a widespread mechanism for developmental evolution.
dc.description.sponsorship This work was supported by the EU project “BioPreDyn” (EC FP7-KBBE-2011-5, grant number 289434)
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher eLife
dc.relation.ispartof Elife. 2015; 4: e04785
dc.rights Copyright Wotton et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.other Drosòfila
dc.subject.other Genètica molecular
dc.subject.other RNA missatger
dc.title Quantitative system drift compensates for altered maternal inputs to the gap gene network of the scuttle fly Megaselia abdita
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.7554/eLife.04785.001
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/289434
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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