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Abnormal Social Reward Responses in Anorexia Nervosa: An fMRI Study.

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dc.contributor.author Via, Esther
dc.contributor.author Soriano Mas, Carles
dc.contributor.author Sánchez, Isabel
dc.contributor.author Forcano, Laura
dc.contributor.author Harrison, Ben J.
dc.contributor.author Davey, Christopher G.
dc.contributor.author Pujol, Jesús
dc.contributor.author Martínez Zalacaín, Ignacio
dc.contributor.author Menchón, José M.
dc.contributor.author Fernández Aranda, Fernando
dc.contributor.author Cardoner, Narcís
dc.date.accessioned 2015-10-07T10:33:19Z
dc.date.available 2015-10-07T10:33:19Z
dc.date.issued 2015
dc.identifier.citation Via E, Soriano-Mas C, Sánchez I, Forcano L, Harrison BJ, Davey CG. et al Abnormal Social Reward Responses in Anorexia Nervosa: An fMRI Study. PLoS One. 2015 Jul 21;10(7):e0133539. doi: 10.1371/journal.pone.0133539.
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10230/24812
dc.description.abstract Patients with anorexia nervosa (AN) display impaired social interactions, implicated in the development and prognosis of the disorder. Importantly, social behavior is modulated by reward-based processes, and dysfunctional at-brain-level reward responses have been involved in AN neurobiological models. However, no prior evidence exists of whether these neural alterations would be equally present in social contexts. In this study, we conducted a cross-sectional social-judgment functional magnetic resonance imaging (fMRI) study of 20 restrictive-subtype AN patients and 20 matched healthy controls. Brain activity during acceptance and rejection was investigated and correlated with severity measures (Eating Disorder Inventory -EDI-2) and with personality traits of interest known to modulate social behavior (The Sensitivity to Punishment and Sensitivity to Reward Questionnaire). Patients showed hypoactivation of the dorsomedial prefrontal cortex (DMPFC) during social acceptance and hyperactivation of visual areas during social rejection. Ventral striatum activation during rejection was positively correlated in patients with clinical severity scores. During acceptance, activation of the frontal opercula-anterior insula and dorsomedial/dorsolateral prefrontal cortices was differentially associated with reward sensitivity between groups. These results suggest an abnormal motivational drive for social stimuli, and involve overlapping social cognition and reward systems leading to a disruption of adaptive responses in the processing of social reward. The specific association of reward-related regions with clinical and psychometric measures suggests the putative involvement of reward structures in the maintenance of pathological behaviors in AN
dc.description.sponsorship This study was supported in part by the Carlos III Health Institute (ISCIII, PI08/1549, PI11/210 and PI14/290) and by Fondos Europeos de Desarrollo Regional (FEDER). CIBERobn and CIBERSAM are both initiatives of ISCIII.). Dr. Soriano-Mas is funded by a ‘Miguel Servet’ contract from the Carlos III Health Institute (I.D. CP10/00604). A/Prof. Harrison is supported by a National Health and Medical Research Council of Australia (NHMRC) Clinical Career Development Fellowship (I.D. 628509). Dr. Davey is supported by a NHMRC Clinical Career Development Fellowship (I.D. 1061757). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartof PLoS One. 2015 Jul 21;10(7):e0133539
dc.rights © 2015 Via et al. This is an open access article distributed under the terms of the http://creativecommons.org/licenses/by/4.0/, which permits/nunrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.other Anorèxia nerviosa
dc.title Abnormal Social Reward Responses in Anorexia Nervosa: An fMRI Study.
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0133539
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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